*Article not assigned to an issue yet
Kalinga Jayani, Samarakoon Kavindya, Siriwardhane Upesha, Yakandawala Deepthi, Adikaram Nimal, Jayasinghe Lalith, Araya Hiroshi, Fujimoto Yoshinori
Keywords: n Acalypha indican , n Diaporthe melonisn , Enzyme inhibition, Phytotoxicity, Naphthalene derivatives
Nine compounds from the fermentation of Diaporthe melonis, an endophytic fungus in the inflorescence of Acalypha indica L. (Euphorbiaceae), were isolated and identified. They are 1,8-dimethoxynaphthalene (1), 8-methoxynaphthalen-1-ol (2), 4-hydroxybenzoic acid (3), 1-(2,6-dihydroxyphenyl)butanone (4), methyl (4-hydroxyphenyl)acetate (5), 3-nitropropanoic acid (6), phomonitroester (7), felinone A (8) and (4R,6R)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-one (9). The EtOAc crude extract resulted in strong cytotoxicity, radicle elongation inhibition and a strong potential to inhibit α-glucosidase enzyme. This is the first report of the strong α-glucosidase and strong phytotoxicity of compound 4.
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National Institute of Fundamental Studies, Kandy, Sri Lanka