Vegetos

References

Abdulazeez M, Ibrahim K, Bulus K, Babvoshia H, Abdullahi Y (2013) Effect of combined use of Ocimum gratissimum and Vernonia amygdalina extract on the activity of angiotensin converting enzyme, hypolipidemic and antioxidant parameters in streptozotocin-induced diabetic rats. Afr J Biochem Res 7:165–173


Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121–126


Akpaso MI, Atangwho IJ, Akpantah A, Fischer VA, Igiri AO, Ebong PE (2011) Effect of combined leaf extracts of Vernonia amygdalina (Bitterleaf) and Gongronema latifolium (Utazi) on the pancreatic β-cells of streptozotocin induced diabetic rats. Br J Med Med Res 1:24–34


Alabi QK, Adeyemi WJ (2021) Vernonia amygdalina (Del) as an antioxidant, aspirin toxicity, and oxidative stress. Academic Press, London


Asante D, Effah-Yeboah E, Barnes P, Abban H, Ameyaw E, Boampong J, Ofori E, Dadzie J (2016) Antidiabetic effect of young and old ethanolic leaf extracts of Vernonia amygdalina: a comparative study. J Diabetes Res 2016:8252741


Asuzu CU (2018) Bitter herbs of eastern Nigeria (Gongronema latifolium, Vernonia amygdalina and Vitex doniana): a review. Afr J Tradit Complement Altern Med 15:47–56


Atangwho IJ, Ebong PE, Eteng MU, Eyong EU, Obi AU (2007) Effects of Vernonia amygdalina Del. leaf on kidney function of diabetic rats. Int J Pharmacol 3:143–148


Batiha E-SG, Beshbishy AM, Wasef LG, Elewa YH, Al-Sagan AA, El-Hack A, Mohamed E, Taha AE, Abd-Elhakim YM, Devkota HP (2020) Chemical constituents and pharmacological activities of garlic (Allium sativum L.): a review. Nutrients 12:872


Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302–310


Erukainure OL, Chukwuma CI, Sanni O, Matsabisa MG, Islam MS (2019) Histochemistry, phenolic content, antioxidant, and anti-diabetic activities of Vernonia amygdalina leaf extract. J Food Biochem 43:e12737


Ezuruike UF, Prieto JM (2014) The use of plants in the traditional management of diabetes in Nigeria. J Ethnopharmacol 155:857–924


Farombi EO (2003) African indigenous plants with chemotherapeutic potentials and biotechnological approach to the production of bioactive prophylactic agents. Afr J Biotechnol 2:662–671


Ghyasi R, Mohaddes G, Naderi R (2019) Combination effect of voluntary exercise and garlic (Allium sativum) on oxidative stress, cholesterol level and histopathology of heart tissue in type 1 diabetic rats. J Cardiovasc Thorac Res 11:61


Gudalwar BR, Nimbalwar MG, Panchale WA, Wadekar AB, Manwar JV, Bakal RL (2021) Allium sativum, a potential phytopharmacological source of natural medicine for better health. GSC Adv Res Rev 6:220–232


Haidari M, Alami K, Hossaini A, Mousavi SY (2020) Effect of Afghan Hibiscus sabdariffa L. and Carum carvi L. hydro-alcoholic extracts either alone or in combination on blood glucose level in diabetic rats. Int J Ayurvedic Med 11:759–764


Hasibuan PAZ, Harahap U, Sitorus P, Satria D (2020) The anticancer activities of Vernonia amygdalina Delile. leaves on 4T1 breast cancer cells through phosphoinositide 3-kinase (PI3K) pathway. Heliyon 6:e04449


Ighodaro OM, Adeosun AM, Ujomu TS, Durosinlorun OO, Okosa CC (2021) Combination therapy of Allium cepa L. and Cucumis sativa L. extracts in streptozotocin-induced diabetic rat model. Future J Pharm Sci 7:1–7


Igwe KK, Okafor PN, Ijeh II (2015) GC–MS analysis of phytocomponents in Vernonia amygdalina del leaves and its contractile potential in mammary tissue in female albino Wistar rats. IOSR J Agric Vet Sci 8:2319–2372


Iheagwam FN, Nsedu EI, Kayode KO, Emiloju OC, Ogunlana OO, Chinedu SN (2018) Bioactive screening and in vitro antioxidant assessment of Nauclea latifolia leaf decoction. AIP Conf Proc 1954:030015


Iheagwam FN, Israel EN, Kayode KO, De Campos OC, Ogunlana OO, Chinedu SN (2019a) GC–MS analysis and inhibitory evaluation of Terminalia catappa leaf extracts on major enzymes linked to diabetes. Evid Based Complement Altern Med 2019:6316231


Iheagwam FN, Ogunlana OO, Chinedu SN (2019b) Model optimization and in silico analysis of potential dipeptidyl peptidase iv antagonists from GC–MS identified compounds in Nauclea latifolia leaf extracts. Int J Mol Sci 20:5913


Iheagwam FN, Batiha GES, Ogunlana OO, Chinedu SN (2021a) Terminalia catappa extract palliates redox imbalance and inflammation in diabetic rats by upregulating Nrf-2 gene. Int J Inflam 2021:9778486


Iheagwam FN, Okeke CO, De Campos OC, Adegboye BE, Ogunlana OO, Chinedu SN (2021b) Toxicopathological, proinflammatory and stress response evaluation of Terminalia catappa extract in male Wistar rats. Toxicol Rep 8:1769–1776


Imaga NO, Iheagwam FN, Nlebedim AO (2022) Antidiabetic potential of Ocimum gratissimum and Vernonia amygdalina combined extract in streptozotocin-induced diabetic rats. Phytothérapie. https://doi.org/10.3166/phyto-2022-0328


Iweala EE, Oludare FD (2011) Hypoglycemic effect, biochemical and histological changes of Spondias mombin Linn. and Parinari polyandra Benth. seeds ethanolic extracts in alloxan-induced diabetic rats. J Pharmacol Toxicol 6:101–112


Kabir N, Alhaji UI, James DB, Inuwa HM, Atiku MK (2021) Effect of the combination of Leptadenia hastata (pers) decne and Momordica balsamina linn leaf extracts on lipid profile of streptozotocin-induced diabetic rats. Future J Pharm Sci 7:1–7


Latifi E, Mohammadpour AA, Fathi B, Nourani H (2019) Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats. Biomed Pharmacother 110:197–202


Lorke D (1983) A new approach to practical acute toxicity testing. Arch Toxicol 54:275–287


Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170–3175


Oh KK (2022) A network pharmacology study to investigate bioactive compounds and signaling pathways of garlic (Allium sativum L.) husk against type 2 diabetes mellitus. J Food Biochem 46:e14106


Okokon JE, Umoh UF, Ekpo BA, Etim EI (2013) Antidiabetic study of combined extracts of Vernonia amygdalina, Ocimum gratissimum, and Gongronema latifolium on alloxan-induced diabetic rats. J Nat Pharm 4:28–31


Olawole TD, Okundigie MI, Rotimi SO, Okwumabua O, Afolabi IS (2018) Preadministration of fermented sorghum diet provides protection against hyperglycemia-induced oxidative stress and suppressed glucose utilization in alloxan-induced diabetic rats. Front Nutr 5:16


Olufunmilayo LA, Oshiobugie MJ, Iyobosa AI (2017) Gas chromatography–mass spectrometry (GC–MS) analysis of phytocomponents in the root, stem bark and leaf of Vernonia amygdalina. World J Pharm Res 6:35–49


Omojokun OS, Famurewa AJ, Jaiyeoba OA, Oboh G, Agbebi OJ (2019) Alkaloid extracts from bitter leaf (Vernonia amygdalina) and black nightshade (Solanum nigrum) inhibit phosphodiesterase-5, arginase activities and oxidative stress in rats penile tissue. J Food Biochem 43:e12889


Ong K, Hsu A, Song L, Huang D, Tan B (2011) Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats. J Ethnopharmacol 133:598–607


Rahmani G, Farajdokht F, Mohaddes G, Babri S, Ebrahimi V, Ebrahimi H (2020) Garlic (Allium sativum) improves anxiety-and depressive-related behaviors and brain oxidative stress in diabetic rats. Arch Physiol Biochem 126:95–100


Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem 25:192–205


Shehadeh MB, Suaifan GA, Abu-Odeh AM (2021) Plants secondary metabolites as blood glucose-lowering molecules. Molecules 26:4333


Subroto E, Cahyana Y, Tensiska M, Filianty F, Lembong E, Wulandari E, Kurniati D, Saputra RA, Faturachman F (2021) Bioactive compounds in garlic (Allium sativum L.) as a source of antioxidants and its potential to improve the immune system: a review. Food Res 5:1–11


Tiwari AK, Rao JM (2002) Diabetes mellitus and multiple therapeutic approaches of phytochemicals: present status and future prospects. Curr Sci 83:30–38


Ugbogu EA, Emmanuel O, Dike ED, Agi GO, Ugbogu OC, Ibe C, Iweala EJ (2021) The phytochemistry, ethnobotanical, and pharmacological potentials of the medicinal plant-Vernonia amygdalina L. (bitter Leaf). Clin Complement Med Pharmacol 1:100006


Yaro AH, Anuka JA, Salawu OA, Magaji MG (2007) Anticonvulsant activities of methanol extract of Chrysnthellum indicum linn. Vatke in mice and chicks. Niger J Pharm Sci 6:22–27


Ziamajidi N, Behrouj H, Abbasalipourkabir R, Lotfi F (2018) Ameliorative effects of Allium sativum extract on iNOS gene expression and NO production in liver of streptozotocin+ nicotinamide-induced diabetic rats. Indian J Clin Biochem 33:147–153


Zito SW, Shinde J, Chen IC, Taldone T, Barletta M (2008) Oral hypoglycemics: a review of chemicals used to treat type 2 diabetes. Curr Bioact Compd 4:68–85