Bioactive metabolites of Anethum graveolens and their applications

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DOI: 10.1007/s42535-025-01196-z
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Keywords: Secondary metabolites, Essential oils, Flavonoids, Seeds


Abstract


Anethum graveolens, a fragrant herb belonging to the Apiaceae family, is extensively cultivated as a spice and flavoring crop. Dill, the common name for Anethum graveolens, is an aromatic plant extensively used in traditional medicine and culinary practices. The plant’s parts and extracts are widely employed in traditional medicines, as food supplements, antimicrobial and insecticidal agents, and in the beverage industry, owing to its distinctive aroma, antioxidant, anticancer, antimicrobial properties, and other biological activities. The essential oil and aerial portions of the plant are widely utilized in food products globally. This review describes the recent advancements regarding the essential oils and other metabolites of Anethum graveolens, their biological properties, and their applications in medicinal, condiment, food, and feed industries. This review explores the bioactive metabolites present in Dill and their potential applications across various industries.

Secondary metabolites, Essential oils, Flavonoids, Seeds


References


Aati HY, Perveen S, Aati S, Orfali R, Alqahtani JH, Al-Taweel AM, Wanner J, Aati AY (2022) Headspace solid-phase microextraction method for extracting volatile constituents from the different parts of Saudi Anethum graveolens L. and their antimicrobial activity. Heliyon 8(3):e09051. https://doi.org/10.1016/j.heliyon.2022.e09051. (PMID: 35299607; PMCID: PMC8920927)


Abbas MA, Oriquat GA et al (2020) Hypolipidaemic and insulin secretagogue activities of (R)-Carvone. Malays J Med Sci 27(6):39–52. https://doi.org/10.21315/mjms2020.27.6.5


Abbasi E, Goodarzi MT et al (2021) Favorable effects of Anethum graveolens on liver oxidative stress and cholesterol 7 alpha-hydroxylase levels in non-alcoholic fatty liver disease (NAFLD) rat models. Metabol Open 14(12):100140. https://doi.org/10.1016/j.metop.2021.100140


Abbasi Oshaghi E, Khodadadi I et al (2015) Lipid lowering effects of hydroalcoholic extract of Anethum graveolens L. and dill tablet in high cholesterol fed hamsters. Cholesterol 2015:958560. https://doi.org/10.1155/2015/958560


Al-Oqail MM, Farshori NN (2021) Antioxidant and anticancer efficacies of Anethum graveolens against human breast carcinoma cells through oxidative stress and caspase dependency. Biomed Res Int 4(2021):5535570. https://doi.org/10.1155/2021/5535570


Alsanea S, Liu D (2017) BITC and S-Carvone restrain high-fat diet-induced obesity and ameliorate hepatic steatosis and insulin resistance. Pharm Res 34(11):2241–2249. https://doi.org/10.1007/s11095-017-2230-3


Al-Sheddi ES, Al-Zaid NA et al (2019a) Evaluation of cytotoxicity, cell cycle arrest and apoptosis induced by Anethum graveolens L. essential oil in human hepatocellular carcinoma cell line. Saudi Pharm J 27(7):1053–1060. https://doi.org/10.1016/j.jsps.2019.09.001


Al-Sheddi ES et al (2019b) Cytotoxicity and mitochondrial-mediated apoptosis induced by fenugreek seed oil in human hepatocellular carcinoma cells via reactive oxygen species generation. Pharmacogn Mag 15(60):12–17. https://doi.org/10.4103/pm.pm_163_18


Arash A, Mohammad MZ et al (2013) Effects of the aqueous extract of Anethum graveolens leaves on seizure induced by pentylenetetrazole in mice. Malays J Med Sci 20(5):23–30


Biesiada A, Kędra K et al (2019) Nutritional value of garden dill (Anethum graveolens L.), depending on genotype. Notulae Botanicae Horti Agrobotanici Cluj Napoca 47(3):784–791


Bošković D, Vuković S, Lazić S, Baser N, Čulum D, Tekić D, Žunić A, Šušnjar A, Šunjka D (2023) Insecticidal activity of selected essential oils against Drosophila suzukii (Diptera: Drosophilidae). Plants (Basel) 12(21):3727. https://doi.org/10.3390/plants12213727.PMID:37960084;PMCID:PMC10647715


Bukharov AF, Baleev DN, Soldatenko AV et al (2021) Impacts of high temperature on embryonic growth and seed germination of dill (Anethum graveolens). Seed Sci Technol 49:7–17. https://doi.org/10.15258/sst.2021.49.1.02





Castro LM, Pinto NB et al (2021) Antihelminthic action of the Anethum graveolens essential oil on Haemonchus contortus eggs and larvae. Braz J Biol 81(1):183–188. https://doi.org/10.1590/1519-6984.225856


Cenizo V, André V, Reymermier C et al (2006) LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression. Exp Dermatol 15(8):574–581. https://doi.org/10.1111/j.1600-0625.2006.00442.x


Cerqueira NM, Oliveira EF, Gesto DS et al (2016) Cholesterol biosynthesis: a mechanistic overview. Biochemistry 55(39):5483–5506. https://doi.org/10.1021/acs.biochem.6b00342


Chen Y, Zeng H, Tian J et al (2013) Antifungal mechanism of essential oil from Anethum graveolens seeds against Candida albicans. J Med Microbiol 62(Pt 8):1175–1183. https://doi.org/10.1099/jmm.0.055467-0. (Epub 2013 May 8)


Chen Y, Zeng H, Tian J et al (2014) Dill (Anethum graveolens L.) seed essential oil induces Candida albicans apoptosis in a metacaspase-dependent manner. Fungal Biol 118(4):394–401. https://doi.org/10.1016/j.funbio.2014.02.004





El Mansouri L, Bousta D et al (2016) Phytochemical screening, antidepressant and analgesic effects of aqueous extract of Anethum graveolens L. from southeast of Morocco. Am J Ther 23(6):e1695–e1699. https://doi.org/10.1097/MJT.0000000000000090





Fhayli W, Boëté Q et al (2020) Dill extract induces elastic fiber neosynthesis and functional improvement in the ascending aorta of aged mice with reversal of age-dependent cardiac hypertrophy and involvement of lysyl oxidase-like-1. Biomolecules 10(2):173. https://doi.org/10.3390/biom10020173


Fleming T (2000) PDR for herbal medicines. Medical Economics Company, Montvale, NJ


Goodarzi MT, Khodadadi I et al (2016) The role of Anethum graveolens L. (Dill) in the management of diabetes. J Trop Med. https://doi.org/10.1155/2016/1098916


Gupta R, Anwer MM, Sharma YK (2012) Dill. Handbook of herbs and spices. Woodhead Publishing, pp 275–285


Haidari F, Zakerkish M et al (2020) The effects of Anethum graveolens (Dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes. Trials 21(1):483. https://doi.org/10.1186/s13063-020-04401-3


Hajhashemi V, Abbasi N (2008) Hypolipidemic activity of Anethum graveolens in rats. Phytother Res 22(3):372–375. https://doi.org/10.1002/ptr.2329. (PMID: 18058989)


Hajji M, Falcimaigne-Gordin A, Ksouda G, Merlier F, Thomasset B, Nasri M (2021) A water-soluble polysaccharide from Anethum graveolens seeds: structural characterization, antioxidant activity and potential use as meat preservative. Int J Biol Macromol 15(167):516–527. https://doi.org/10.1016/j.ijbiomac.2020.12.006. (Epub 2020 Dec 3. PMID: 33279565)


Hao Y, Kang J, Guo X, Yang R, Chen Y, Li J, Shi L (2021) Comparison of nutritional compositions and essential oil profiles of different parts of a dill and two fennel cultivars. Foods 10(8):1784. https://doi.org/10.3390/foods10081784


Hernández-Cánovas JD, Guillén-López I et al (2020) Antimicrobial activity of Citrus spp. and Anethum graveolens components against Candida metapsilosis in ranch sauce. J Food Sci Technol 57(7):2713–2721. https://doi.org/10.1007/s13197-020-04307-7


Iamsaard S, Prabsattroo T et al (2013) Anethum graveolens Linn. (Dill) extract enhances the mounting frequency and level of testicular tyrosine protein phosphorylation in rats. J Zhejiang Univ Sci B 14(3):247–252. https://doi.org/10.1631/jzus.B1200287


Idiz C, Aysan E et al (2018) Effectiveness of Anethum Graveolens L. on antioxidant status, thyroid function and histopathology. Acta Endocrinol (Buchar). 14(4):447–452. https://doi.org/10.4183/aeb.2018.447


Istvan ES, Deisenhofer J (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292(5519):1160–1164. https://doi.org/10.1126/science.1059344


Jana S, Shekhawat GS (2010) Anethum graveolens: an Indian traditional medicinal herb and spice. Pharmacogn Rev 4(8):179–184. https://doi.org/10.4103/0973-7847.70915


Jang SA, Lee SJ, Hwang YH, Ha H (2023) Anti-osteoporotic potential of water extract of Anethum graveolens L. Seeds Nutrients 15(19):4302. https://doi.org/10.3390/nu15194302.PMID:37836586;PMCID:PMC10574365


Japheth KP, Kumaresan A et al (2021) Supplementation of a combination of herbs improves immunity, uterine cleansing and facilitate early resumption of ovarian cyclicity: a study on post-partum dairy buffaloes. J Ethnopharmacol 3(272):113931. https://doi.org/10.1016/j.jep.2021.113931


Kalangi SK, Dayakar A et al (2016) Biocompatible silver nanoparticles reduced from Anethum graveolens leaf extract augments the antileishmanial efficacy of miltefosine. Exp Parasitol 170:184–192. https://doi.org/10.1016/j.exppara.2016.09.002


Kazemi M (2015) Phenolic profile, antioxidant capacity and anti-inflammatory activity of Anethum graveolens L. essential oil. Nat Prod Res 29:551–553. https://doi.org/10.1080/14786419.2014.951934


Khalaf AF (2004) Toxicological efficacy of some indigenous dill compounds against the flesh fly, Parasarcophaga dux Thomson. J Egypt Soc Parasitol 34(1):227–237


Kim YJ, Shin Y et al (2012) Anethum graveloens flower extracts inhibited a lipopolysaccharide-induced inflammatory response by blocking iNOS expression and NF-κB activity in macrophages. Biosci Biotechnol Biochem 76(6):1122–1127. https://doi.org/10.1271/bbb.110950. (Epub 2012 Jun 7)








Madani H, Mahmoodabady NA, Vahdati A (2005) Effects of hydroalcoholic extract of Anethum graveolens (Dill) on plasma glucose and lipid levels in diabetes induced rats. Iran J Diabetes Metab 5(2):109–116


Madhava Naidu M, Vedashree M et al (2016) Effect of drying methods on the quality characteristics of dill (Anethum graveolens) greens. Food Chem 1(192):849–856. https://doi.org/10.1016/j.foodchem.2015.07.076. (Epub 2015 Jul 20)


Malihezaman M, Mojaba M et al (2012) Anti-fertility effects of different fractions of Anethum graveolens L. extracts on female rats. Afr J Tradit Complement Altern Med 9(3):336–341. https://doi.org/10.4314/ajtcam.v9i3.6


Manzuoerh R, Farahpour MR et al (2019) Effectiveness of topical administration of Anethum graveolens essential oil on MRSA-infected wounds. Biomed Pharmacother 109:1650–1658. https://doi.org/10.1016/j.biopha.2018.10.117


Mashraqi A (2023) Induction role of chitosan nanoparticles to Anethum graveolens extract against food-borne bacteria, oxidant, and diabetic activities in vitro. Front Microbiol 4(14):1209524. https://doi.org/10.3389/fmicb.2023.1209524.PMID:37469433;PMCID:PMC10352794


Meza D, Li WH et al (2020) A blackberry-dill extract combination synergistically increases skin elasticity. Int J Cosmet Sci 42(5):444–451. https://doi.org/10.1111/ics.12644


Milenković L, Ilić ZS, Stanojević L, Danilović B, Šunić L, Kevrešan Ž, Stanojević J, Cvetković D (2024) Chemical Composition and Bioactivity of Dill Seed (Anethum graveolens L.) essential oil from plants grown under shading. Plants (Basel) 13(6):886. https://doi.org/10.3390/plants13060886. (PMID: 38592874; PMCID: PMC10974297)











Monsefi M, Khalifeh B, Nikeghbal S (2018) Effects of Anethum graveolens L. on In vitro matured mouse oocytes and granulosa cells. Avicenna J Med Biotechnol 10(4):220–226


Mujović M, Šojić B, Peulić T, Kocić-Tanackov S, Ikonić P, Božović D, Teslić N, Županjac M, Novaković S, Jokanović M, Škaljac S, Pavlić B (2024) Effects of dill (Anethum graveolens) essential oil and lipid extracts as novel antioxidants and antimicrobial agents on the quality of beef burger. Foods 13(6):896. https://doi.org/10.3390/foods13060896.PMID:38540886;PMCID:PMC10969687


Muruganathan U, Srinivasan S (2016) Beneficial effect of carvone, a dietary monoterpene ameliorates hyperglycemia by regulating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats. Biomed Pharmacother 84:1558–1567. https://doi.org/10.1016/j.biopha.2016.11.025


Nair R, Chanda S (2007) Antibacterial activities of some medicinal plants of the western region of India. Turk J Biol 31:231–236


Nam HH, Nan L, Choo BK (2021) Anti-inflammation and protective effects of Anethum graveolens L. (Dill seeds) on esophageal mucosa damages in reflux esophagitis-induced rats. Foods 10(10):2500. https://doi.org/10.3390/foods10102500. (PMID: 34681549; PMCID: PMC8535990)





Ninou EG, Mylonas IG et al (2017) Phenotypic diversity of Greek dill (Anethum graveolens L.) landraces. Acta Agric Sc Sect B Soil Plant Sci. https://doi.org/10.1080/09064710.2016.1276957


Osanloo M, Ghaznavi G, Abdollahi A (2020) Surveying the chemical composition and antibacterial activity of essential oils from selected medicinal plants against human pathogens. Iran J Microbiol 12(6):577–583. https://doi.org/10.18502/ijm.v12i6.5032.PMID:33613912;PMCID:PMC7884278


Oshaghi EA, Khodadadi I et al (2016a) Aqueous extract of Anethum Graveolens L. has potential antioxidant and antiglycation effects. Iran J Med Sci 41(4):328–333


Oshaghi EA, Khodadadi I et al (2016b) Effect of dill tablet (Anethum graveolens L) on antioxidant status and biochemical factors on carbon tetrachloride-induced liver damage on rat. Int J Appl Basic Med Res 6(2):111–114. https://doi.org/10.4103/2229-516X.179019


Panda S (2008) The effect of Anethum graveolens L. (Dill) on corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Phytother Res 22(12):1695–1697


Râpă M, Gaidau C, Mititelu-Tartau L et al (2021) Bioactive collagen hydrolysate-chitosan/essential oil electrospun nanofibers designed for medical wound dressings. Pharmaceutics 13(11):1939. https://doi.org/10.3390/pharmaceutics13111939





Ravindran P, Balachandran I (2005) Under utilized medicinal spices II, Spice India. Flight. 17. Publisher VK Krishnan Nair, India, pp. 32–6


Saghafi N, Karjalian M et al (2018) The effect of a vaginal suppository formulation of dill (Anethum graveolens) in comparison to clotrimazole vaginal tablet on the treatment of vulvovaginal candidiasis. J Obstet Gynaecol 38(7):985–988. https://doi.org/10.1080/01443615.2018.1432578. (Epub 2018 Mar 19)


Sakurai K, Ogiso T (1995) Effect of ferritin on lambda DNA strand breaks in the reaction system of alloxan plus NADPH-cytochrome P450 reductase: ferritin’s role in diabetogenic action of alloxan. Biol Pharm Bull 18(2):262–266. https://doi.org/10.1248/bpb.18.262


Salini R, Pandian SK (2015) Interference of quorum sensing in urinary pathogen Serratia marcescens by Anethum graveolens. Pathog Dis 73(6):ftv038. https://doi.org/10.1093/femspd/ftv038


Setorki M, Rafieian-Kopaei M et al (2013a) Suppressive impact of Anethum graveolens consumption on biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits. Int J Prev Med 4(8):889–895


Setorkil M et al (2013b) Comparison between the effects of hydroalcoholic extract of dill and statins on lipid profile. J Kerman Univ Med Sci 20(2):158–168


Shafaei N, Barkhordar SMA et al (2020) Protective effects of Anethum graveolens seed’s oil nanoemulsion against cadmium-induced oxidative stress in mice. Biol Trace Elem Res 198(2):583–591. https://doi.org/10.1007/s12011-020-02093-z


Sharma R, Salwan R, Sharma M et al (2023) Biochemical characterization of volatile compounds and antimicrobial activity of Anethum graveolens seeds. Vegetos. https://doi.org/10.1007/s42535-023-00641-1


Sharma R, Salwan R, Dwivedi N et al (2024a) Exploration of Anethum graveolens diversity from north western Himalayan. J Appl Res Med Aromat Plants 42:100559. https://doi.org/10.1016/j.jarmap.2024.100559


Sharma R, Salwan R, Sharma V (2024b) GC-MS analysis of essential oil and exploration of Anethum graveolens extracts for antimicrobial and antioxidant activity. Vegetos 42:100559. https://doi.org/10.1007/s42535-024-00884-6


Singh G, Maurya S, de Lampasona MP, Catalan C (2005) Chemical constituents, antimicrobial investigations, and antioxidative potentials of Anethum graveolens L. essential oil and acetone extract. J Food Sci 70(4):208–215


Snuossi M, Trabelsi N et al (2016) Laurus nobilis, Zingiber officinale and Anethum graveolens essential oils: composition, antioxidant and antibacterial activities against bacteria isolated from fish and shellfish. Molecules 21(10):1414. https://doi.org/10.3390/molecules21101414


Sohm B, Cenizo V et al (2011) Evaluation of the efficacy of a dill extract in vitro and in vivo. Int J Cosmet Sci 33(2):157–163. https://doi.org/10.1111/j.1468-2494.2010.00606.x


Solouki M, Hoseini SB et al (2012) Genetic diversity in dill (Anethum graveolens L.) populations on the basis of morphological traits and molecular markers. Afr J Biotechnol 11(15):3649. https://doi.org/10.5897/AJB11.2169


Sung JS, Chung JW et al (2013) Genetic diversity and phenetic relationship of dill (Anethum graveolens L.) by rps16-trnK DNA sequences. J Life Sci 23(11):1305–1310


Suresh S, Chung JW et al (2013) Analysis of genetic diversity and population structure of 135 dill (Anethum graveolens L.) accessions using RAPD markers. Genet Resour Crop Evol 60:893–903


Taddeo VA, Genovese S et al (2017) Quantification of biologically active O-prenylated and unprenylated phenylpropanoids in dill (Anethum graveolens), anise (Pimpinella anisum), and wild celery (Angelica archangelica). J Pharm Biomed Anal 5(134):319–324. https://doi.org/10.1016/j.jpba.2016.11.048


Taddeo VA, Epifano F et al (2019) HPLC Analysis and skin whitening effects of umbelliprenin-containing extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris. Molecules 24(3):501. https://doi.org/10.3390/molecules24030501


Talebi F, Malchi F et al (2020) Effect of dill (Anethum Graveolens Linn) seed on the duration of labor: a systematic review. Complement Ther Clin Pract 41:101251. https://doi.org/10.1016/j.ctcp.2020.101251. (Epub 2020 Oct 28. PMID: 33130423)


Tavakkol Afshari HS, Homayouni Tabrizi M et al (2021) Anethum Graveolens essential oil nanoemulsions (AGEO-NE) as an exclusive apoptotic inducer in human lung adenocarcinoma (A549) cells. Nutr Cancer 74(4):1411–1419

 


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University Center for Research and Development, Chandigarh University, Mohali, India