Vegetos

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Research Articles | Published: 20 November, 2025

References

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Adam OA, Abadi RS, Ayoub SM (2019) The effect of extraction method and solvents on yield and antioxidant activity of certain Sudanese medicinal plant extracts. J Phytopharmacol 8(5):248–252


Armanini D, Mattarello MJ, Fiore C, Bonanni G, Scaroni C, Sartorato P, Palermo M (2004) Licorice reduces serum testosterone in healthy women. Steroids 69(11–12):763–766


Aruoma OI (2003) Methodological considerations for characterizing potential antioxidant actions of bioactive components in plant foods. Mutat Res Fundam Mol Mechan Mutag 523:9–20. https://doi.org/10.1016/S0027-5107(02)00317-2


Bai DS, Suvarchala V, Pavani C, Chaithanya G, Spoorthi V, Shasthree T (2021) Qualitative and quantitative evaluation of secondary metabolites of different plant extracts of Nothapodytes foetida (Wight) Sleumer an important endangered medicinal tree. World Sci News 162:43–59


Benedec D, Vlase L, Oniga I, Mot AC, Damian G, Hanganu D, Duma M, Silaghi-Dumitrescu R (2013) Polyphenolic composition, antioxidant and antibacterial activities for two Romanian subspecies of Achillea distans Waldst. et Kit. ex Willd. Molecules 18(8):8725–8739. https://doi.org/10.3390/MOLECULES18088725


Blois MS (1958) Antioxidant determinations by the use of a stable free radical. Nature 181(4617):1199–1200


Brand-Williams W, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. LWT Food Sci Technol 28(1):25–30


Brown JE, Rice-Evans CA (1998) Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radic Res 29(3):247–255. https://doi.org/10.1080/10715769800300281


Budzianowski J, Budzianowska A (2006) Phenolic glycosides from Lysimachia clethroides Duby. Acta Pol Pharm 63(6):405–410


Campbell MK, Carr C, DeVellis B, Switzer B, Biddle A, Amamoo MA, Walsh J, Zhou B, Sandler R (2009) A randomized trial of tailoring and motivational interviewing to promote fruit and vegetable consumption for cancer prevention and control. Ann Behav Med 38(2):71–85. https://doi.org/10.1007/S12160-009-9140-5


Číž M, Čížová H, Denev P, Kratchanova M, Slavov A, Lojek A (2010) Different methods for control and comparison of the antioxidant properties of vegetables. Food Control 21(4):518–523. https://doi.org/10.1016/J.FOODCONT.2009.07.017


Dangi S, Parajuli N (2022) Phytochemical analysis, antioxidant and antibacterial activities of methanolic rhizome extract of Bergenia pacumbis: a valuable medicinal herb. BIBECHANA 19(1–2):14–26


Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Srimal RC, Tandon JS (1973) Screening of Indian plants for biological activity. IV. Indian J Exp Biol.


Dixit A, Gayakwad S, Shirolkar A, Warkad S, Devlae A, Murthy SN, Pawar S (2015) Phytochemical characterization and cells based analysis of bioactive components of Nothapodytes nimmoniana (J. Graham). Int J Curr Microbiol App Sci 2:18–37


Dizdaroglu M, Jaruga P (2012) Mechanisms of free radical-induced damage to DNA. Free Radic Res 46(4):382–419. https://doi.org/10.3109/10715762.2011.653969


Dubey NK, Kumar R, Tripathi P (2004) Global promotion of herbal medicine: India’s opportunity. Curr Sci 86(1):37–41


Durga B, Julius A, Raghavendra JS (2020) Review of pharmacological aspects of Nothapodytes nimmoniana species. Eur J Mol Clin Med 7(03):1727–1732


Gao S, Liu G, Wang Z, Xu Y, Zhang J, Yang Z (2011) Total phenolic contents, antioxidant activities, and chemical compositions of six Camellia species. J Agric Food Chem 59(23):12330–12336


Gouthamchandra K, Mahmood R, Manjunatha H (2010) Free radical scavenging, antioxidant enzymes and wound healing activities of leaves extracts from Clerodendrum infortunatum L. Environ Toxicol Pharmacol 30(1):11–18. https://doi.org/10.1016/J.ETAP.2010.03.005


Green CL (1994) Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Infect Immun 62:1171


Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 126(1):131–138


Gupta P, Kumar R (2024) Nitric oxide: a potential etiological agent for vaso-occlusive crises in sickle cell disease. Nitric Oxide 144:40–46


Gupta S, Kumar MS, Duraiswamy B, Chhajed M, Chhajed A (2012) In-vitro antioxidant and free radical scavenging activities of Ocimum sanctum. World J Pharma Res 1(1):78–92


Halliwell B (1995) How to characterize an antioxidant: an update. InBiochemical Society Symposia (Vol. 61, pp. 73–101). Portland Press Limited.


Harborne JB (1998) Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis, 3rd edn. Chapman & Hall, London


Hayyan M, Hashim MA, AlNashef IM (2016) Superoxide ion: generation and chemical implications. Chem Rev. 116(5):3029–85


Herber RF, Stoeppler M, editors (1994) Trace element analysis in biological specimens. Elsevier.


Himesh S, Sarvesh S, Sharan PS, Mishra K, Singhai AK (2011) Preliminary phytochemical screening and HPLC analysis of flavonoid from methanolic extract of leaves of Annona squamosa. Int Res J Pharm 2(5):242–246


Hong G (2020) Enoxolone suppresses apoptosis in chondrocytes and progression of osteoarthritis via modulating the ERK1/2 signaling pathway. Arch Med Sci 20(3):947–961. https://doi.org/10.5114/aoms.2020.93211


Hossain MA, AL-Raqmi KA, AL-Mijizy ZH, Weli AM, Al-Riyami Q (2013) Study of total phenol, flavonoids contents and phytochemical screening of various leaves crude extracts of locally grown Thymus vulgaris. Asian Pac J Trop Biomed 3(9):705–710. https://doi.org/10.1016/S2221-1691(13)60142-2


Kähkönen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala TS, Heinonen M (1999) Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem 47(10):3954–3962. https://doi.org/10.1021/JF990146L


Keshavan B, Srinivas NS, Tamizh MM, Vairamani M, Pachaiappan R (2022) In vitro elicitation of camptothecin by challenging with biotic elicitors in Nothapodytes nimmoniana (J. Graham) Mabb. S Afr J Bot 144:325–331


Khan N, Tamboli ET, Sharma VK, Kumar S (2013) Phytochemical and pharmacological aspects of Nothapodytes nimmoniana. An overview. Herba Pol. https://doi.org/10.2478/hepo-2013-0006


Khatoon M, Islam E, Islam R, Rahman AA, Alam AK, Khondkar P, Rashid M, Parvin S (2013) Estimation of total phenol and in vitro antioxidant activity of Albizia procera leaves. BMC Res Notes 2:1–7. https://doi.org/10.1186/1756-0500-6-121/TABLES/2


Krishna TM, Shiva D, Keerthi D, Nandini A, Aswaq A, Reddy T (2013) In vitro evaluation of antioxidant properties of Cucumis melo L extracts of leaves and fruit. Int J Pharm Bio Sci. 4(1):705–12


La Vecchia C, Altieri A, Tavani A (2001) Vegetables, fruit, antioxidants and cancer: a review of Italian studies. Eur J Nutr 40:261–267. https://doi.org/10.1007/S394-001-8354-9/METRICS


Lanjwani AH, Ghanghro IH, Ghanghro AB, Khuhawar TM, Channa MJ (2015) Qualitative examination of phytochemicals from some indiginous medicinal plants. Sindh Univ Res J-SURJ (Sci Ser.) 47(2):1045


Liu RH (2002) Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 78(3 Suppl):517S-520S


Lobo V, Patil A, Phatak A, Chandra N (2010) Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev 4(8):118. https://doi.org/10.4103/0973-7847.70902


Maharjan BL, Baral B (2013) Antioxidant capacity and phenolic content of some Nepalese medicinal plants. Am J Plant Sci. https://doi.org/10.4236/AJPS.2013.48200


Mahendran G, Kumari BR (2016) Biological activities of silver nanoparticles from Nothapodytes nimmoniana (Graham) Mabb. fruit extracts. Food Sci Hum Wellness 5(4):207–218


Miliauskas G, Venskutonis PR, Van Beek TA (2004) Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem 85(2):231–237. https://doi.org/10.1016/J.FOODCHEM.2003.05.007


Mirzaei A, Toori MA, Mirzaei N, Shirazi RG (2013) Antioxidant, antimicrobial and antimutogenic potential of 4 Iranian medicinal plants. Life Sci J 10(7):1085–1091


Musavi SF (2013) Biodiversity, antimicrobial potential, and phylogenetic placement of an endophytic Fusarium oxysporum NFX 06 isolated from Nothapodytes foetida. J Mycol 1:172056. https://doi.org/10.1155/2013/172056


Namdeo AG, Sharma A, Fulzele DP, Mahadik KR (2010) Influence of geographical and climatic conditions on camptothecin content of Nothapodytes nimmoniana. Rec Nat Prod 4(1):64


Narender Prasad D, Rao BG, Rao SE, Rao T, Praneeth DVS (2012) Quantification of phytochemical constituents and in-vitro antioxidant activity of mesua ferrea leaves. Asian Pac J Trop Biomed 2(2):S539–S542. https://doi.org/10.1016/S2221-1691(12)60269-X


Nowicka B, Kruk J (2010) Occurrence, biosynthesis and function of isoprenoid quinones. Biochim Biophys Acta 1797(9):1587–1605


Oliveira I, Sousa A, Ferreira IC, Bento A, Estevinho L, Pereira JA (2008) Total phenols, antioxidant potential and antimicrobial activity of walnut (Juglans regia L.) green husks. Food Chem Toxicol 46(7):2326–2331. https://doi.org/10.1016/J.FCT.2008.03.017


Padmanabha BV, Chandrashekar M, Ramesha BT, Gowda HH, Gunaga RP, Suhas S, Vasudeva R, Ganeshaiah KN, Shaanker RU (2006) Patterns of accumulation of camptothecin, an anti-cancer alkaloid in Nothapodytes nimmoniana Graham., in the Western Ghats, India: implications for identifying high-yielding sources of the alkaloid. Current Science, 95–100. https://www.jstor.org/stable/24089023?casa_token=sDoP1EnCG_8AAAAA%3Ago55AppaPxKn67MHsIKiRjwhmEIzORbBjkx9m2YwnM0gCX75eK0Z-Fiu8NTEozMiYgyTcEJD-14bY3ECO-0jDNZ-YIKZadQFlnzRKoaFnvcx4u27jII.


Papas AM (2019) Diet and antioxidant status. Antiox Status Diet Nut Health 5:89–106. https://doi.org/10.1201/9780367811099-5


Park BK, Kitteringham NR, Powell H, Pirmohamed M (2001) Managing the challenge of chemically reactive metabolites in drug development. Annu Rev Pharmacol Toxicol 41:443–470


Pathak N, Agrawal S (2014) Atomic absorption spectrophotometer analysis for determination of variation in mineral content in fenugreek genotypes cultivated at three different locations. Int J Pharm Sci Invent 3:40–45


Patwardhan A (2024) Domestication of Nothapodytes Nimmoniana - The Rufford Foundation. The rufford small grants foundation, UK. 7–15. https://www.rufford.org/projects/ankur-patwardhan/domestication-of-nothapodytes-nimmoniana/ (accessed 2024–12–20).


Pluskal T, Castillo S, Villar-Briones A, Orešič M (2010) MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC bioinformatics 1–1.


Rai VR, Malleshappa H (2012) Conservation of Nothapodytes nimmoniana (Grah) Mabb.: a potent source of camptothecin, an anti-cancer alkaloid. Physiol Mol Biol Plants 18(2):107–114. https://doi.org/10.1007/s12298-012-0110-7


Raman N (2006) Phytochemical techniques. New India Publishing Agency, New Delhi, pp 19–24


Ramesha BT, Amna T, Ravikanth G, Gunaga RP, Vasudeva R, Ganeshaiah KN, Uma Shaanker R, Khajuria RK, Puri SC, Qazi GN (2008) Prospecting for camptothecines from Nothapodytes nimmoniana in the Western Ghats, South India: identification of high-yielding sources of camptothecin and new families of camptothecines. J Chromatogr Sci 46(4):362–368. https://doi.org/10.1093/chromsci/46.4.362


Rao BG, Rao ES, Rao TM (2012) Quantification of phytochemical constituents and in-vitro antioxidant activity of Mesua ferrea leaves. Asian Pac J Trop Biomed 2(2):S539–S542


Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26(9–10):1231–1237. https://doi.org/10.1016/S0891-5849(98)00315-3


Sankaranarayanan R, Sumathy S (2013) Antioxidant and antihemolytic activity of flavonoid extract from fruit peel of Punicagranatum. Asian J Pharm Clin Res 2:211–214


Sarma J, Baruah S, Borthakur SK (2013) Rediscovery of an endangered plant Nothapodytes nimmoniana (J. Graham) Mabberly from Tinsukia District. Assam NeBio 4(5):10–1


Senguttuvan J, Paulsamy S, Karthika K (2014) Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, Hypochaeris radicata L for in vitro antioxidant activities. Asian Pacific J Trop Biomed 4:359–67. https://doi.org/10.12980/APJTB.4.2014C1030


Shah R, Kathad H, Sheth R, Sheth N (2010) In vitro antioxidant activity of roots of Tephrosia purpurea Linn. Int J Pharm Sci 2(3):30–33


Shaikh JR, Patil M (2020) Qualitative tests for preliminary phytochemical screening: an overview. Int J Chem Stud 8(2):603–608


Sharma MV, Uma Shaanker R, Leather SR, Vasudeva R, Shivanna KR (2011) Floral resources, pollinators and fruiting in a threatened tropical deciduous tree. J Plant Ecol 4(4):259–267. https://doi.org/10.1093/JPE/RTQ029


Sheeja E, Edwin E, Dhanbal SP, Suresh B (2005) Antiinflammatory activity of the leaves of Nothapodytes foetida, miers. Indian J Pharm Sci. 67(2):251–253


Shinde AV, Patil AG, Kamble SY (2022) In vitro propagation and conservation of Nothapodytes nimmoniana–An endangered medicinal plant. Plant cell. Tissue Organ Culture (PCTOC) 150:317–325. https://doi.org/10.1007/s11240-022-02281-4


Simopoulos AP (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. J Am Coll Nutr 21(6):495–505


Susanna D, Balakrishnan RM, Ettiyappan JP (2022) Comprehensive insight into the extract optimization, phytochemical profiling, and biological evaluation of the medicinal plant Nothapodytes foetida. Biocatal Agric Biotechnol 22:1–17. https://doi.org/10.1016/j.bcab.2022.102365


Terry P, Terry JB, Wolk A (2001) Fruit and vegetable consumption in the prevention of cancer: an update. J Intern Med 250(4):280–290. https://doi.org/10.1111/J.1365-2796.2001.00886.X


Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H (2011) Phytochemical screening and extraction: a review: intern. Pharmaceut Sci 1(1):145


Trease GE, Evans WC (2002) Pharmacognosy, 15th edn. Saunders, London


Tura D, Robards K (2002) Sample handling strategies for the determination of biophenols in food and plants. J Chromatogr A 975(1):71–93. https://doi.org/10.1016/S0021-9673(02)00879-8


Ulusoy NG, Emirdağ S, Sözer E, Radwan MO, Çiftçi H, Aksel M, Bölükbaşı SŞ, Özmen A, Yaylı N, Karayıldırım T, Alankuş Ö (2022) Design, semi-synthesis and examination of new gypsogenin derivatives against leukemia via Abl tyrosine kinase inhibition and apoptosis induction. Int J Biol Macromol 222:1487–1499


Vasudha DR, Raveesha HR (2021) In vitro embryo culture, phytochemical investigation and antioxidant activity of Nothapodytes nimmoniana (GRAHAM) mabb. Plant Cell Biotechnol Mol Biol 22(19–20):111–122


Ved D (1997) Trade in medicinal plants- the state of our ignorance. Amruth 1:2–8


Vishnu R, Nisha R, Senguttuvan J, Paulsamy S (2013) Quantification of total phenolics and flavonoids and evaluation of in vitro antioxidant properties of methanolic leaf extract of Tarenna asiatica-an endemic medicinal plant species of Maruthamali hills, Western Ghats. Tami Nadu J Res Plant Sci. 2:196–204


Wagner H, Bladt S. Alkaloid drugs (1996) Plant Drug Analysis: A Thin Layer Chromatography. Atlas 3–51


Wall ME, Wani MC, Cook CE, Palmer KH, McPhail AT, Sim GA (1966) Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc. 88(16):3888–90


Watase I, Sudo H, Yamazaki M, Saito K (2024) Regeneration of transformed Ophiorrhiza pumila plants producing camptothecin. Plant Biotechnology 21(5):337–342. https://doi.org/10.5511/PLANTBIOTECHNOLOGY.21.337


Wu TS, Leu YL, Hsu HC, Ou LF, Chen CC, Chen CF, Ou JC, Wu YC (1995) Constituents and cytotoxic principles of Nothapodytes foetida. Phytochemistry 39(2):383–385. https://doi.org/10.1016/0031-9422(94)00901-5


Zhao Y, Wang J, Balogun CO, Wang N, Zhang M, Lin L (2014) Anticancer properties evaluation of a novel compound isolated from Garcinia xanthochymus. Med Chem Res 23:4249–4260

 

Author Information

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Department of Zoology, Gauhati University, Jalukbari, India