*Article not assigned to an issue yet
Aijaz Farha, Shadab Mo, Akhtar Nazish, Parveen Uzma, Siddiqui M. B.
Keywords: Fleabane, Allelochemicals, Eco-friendly weed management, Weedicide, Pharmacological activity, Medicinal properties
Erigeron bonariensis L. (syn. Conyza bonariensis), a member of the Asteraceae family, has gained considerable scientific attention because of its medicinal and allelopathic potential. This review provides an overview of botanical characteristics, distribution, and phytochemical composition of E. bonariensis, highlighting its bioactive compounds with therapeutic and allelopathic significance. Rich in secondary metabolites, such as phenolic acids, flavonoids, terpenoids, alkaloids, and sesquiterpene lactones, the plant exhibits potent antioxidant, anti-inflammatory, and antimicrobial activities. Traditionally used to treat a wide range of ailments, it also demonstrates strong allelopathic effects by releasing biochemical compounds that suppress the growth of surrounding plant species. Compounds such as (4Z)-lachnophyllum lactone, which mediates allelopathic potential, offer opportunities for eco-friendly weed management in agriculture. Beyond its herbicidal activity, E. bonariensis has shown potential in managing other agricultural pests, including fungi, nematodes, insects, and bacteria, thereby presenting itself as a multitarget natural pest control agent. These multifunctional properties make it a promising candidate for developing eco-friendly bioherbicides and biopesticides, reducing reliance on synthetic agrochemicals. The use of synthetic pesticides disturbs the ecology of biotic communities, and is hazardous to the environment and human health. However, limited comparative studies with related invasive Asteraceae species and inconsistent phytochemical extraction protocols have hindered their broader application. This review underscores the dual ecological and pharmacological roles of E. bonariensis and advocates its integration into sustainable agriculture and healthcare systems. This further suggests that utilizing invasive species, such as E. bonariensis, for beneficial purposes can turn biological threats into valuable biotechnological assets.
Adande K, Eloh K, Simalou O, Bakaï MF, Caboni P (2023) Chemical composition of different extracts of Conyza bonariensis: Insecticidal and nematicidal activities. Am J Anal Chem 14:95–120
Ahmad M, Khan A, Farooq M, Gul S (2023) Allelopathic effects of Erigeron bonariensis on seed germination and seedling growth of crop plants. Allelopathy J 59:55–64
Araujo L, Moujir LM, Rojas J, Rojas L, Carmona J, Rondón M (2013) Chemical composition and biological activity of Erigeron bonariensis essential oil collected in Mérida, Venezuela. Nat Prod Commun 8:1–6
Aslam H, Khan AU, Naureen H, Ali F, Ullah F, Sadiq A (2018) Potential application of Erigeron canadensis (L.) Cronquist in the management of diabetes: In vitro and in vivo evaluation. Trop J Pharm Res 17:1287–1293
Balah MA, Al-Andal A, Radwan AM, Donia AEM (2024) Unveiling allelopathic dynamics and impacts of invasive Erigeron bonariensis and Bidens pilosa on plant communities and soil parameters. Sci Rep 14:10159
Batista AF, Cruz DS, Freitas RM (2021) Allelopathic effects of Erigeron bonariensis (L) on seed germination and seedling growth of crops and weeds. Allelopathy J 53:73–86. https://doi.org/10.26651/allelo.j/2021-53-1-1240
Blowman K, Magalhães M, Lemos MFL, Cabral C, Pires IM (2018) Anticancer properties of essential oils and other natural products. Evid Based Complement Alternat Med 2018:3149362
Bukhari IA, Shah AJ, Khan RA, Meo SA, Khan A, Gilani AH (2013) Gut modulator effects of Erigeron bonariensis explain its traditional use in constipation and diarrhea. Eur Rev Med Pharmacol Sci 17:552–558
Bukhari IA, Sheikh SA, Shaikh NA, Assiri AM, Gilani AH (2018) Peripheral analgesic and anti-inflammatory activities of the methanolic extracts of Conyza bonariensis and its fractions in rodents models. Int J Pharmacol 14:144–150
Chanda S, Dave R (2009) In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: an overview. Afr J Microbiol Res 3:981–996
Chauhan NS, Sharma A, Gupta S (2019) Diuretic and detoxifying effects of herbal remedies: A review. J Herb Med 15:1–12
Chowdhury R, Sengupta C, Bhattacharya A (2023) Role of phenolic allelochemicals in invasive plant dominance: a case study on Erigeron spp. Front Plant Sci 14:1157084. https://doi.org/10.3389/fpls.2023.1157084
Cock IE, Van Vuuren SF (2020) A review of the traditional use of southern African medicinal plants for the treatment of fungal skin infections. J Ethnopharmacol 251:112539
Costa RM, Santos FC, Pereira MA (2022) Free radical scavenging activity of Erigeron bonariensis essential oils. J Med Plant Res 16:254–263
Csupor-Löffler B, Hajdú Z, Zupkó I, Molnár J, Forgo P, Vasas A et al (2011) Antiproliferative constituents of the roots of Erigeron canadensis. Planta Med 77:1183–1188
Dai J, Mumper RJ (2010) Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15:7313–7352
de Lima JC, Pinheiro ALB, de Albuquerque UP, Dos Santos JP (2013) Use and knowledge of Cerrado plant species with medicinal properties by residents of Chapada dos Guimarães, Mato Grosso State, Brazil. Acta Bot Bras 27:613–626
Dematteis M, García M, Haro J, Vásquez R, Molina R (2012) Plantas medicinales de la flora de Argentina con acción diurética. Acta Farm Bonaerense 31:172–179
Ekor M (2014) The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 4:177
Elgamal AM, Ahmed RF, Abd-ElGawad AM, El Gendy AENG, Elshamy AI, Nassar MI (2021) Chemical profiles, anticancer, and anti-aging activities of essential oils of Pluchea dioscoridis (L) DC and Erigeron bonariensis L. Plants 10:667
Espinoza RV, Peñarreta J, Quijano-Avilés M, Lucas AB, Chóez-Guaranda I, Santana PM (2020) Antioxidant activity and GC-MS profile of Erigeron bonariensis L. leaves extract and fractions. Rev Fac Nac Agron Medellín 73:9305–9313
Fennell CW, Lindsey KL, McGaw LJ, Sparg SG, Stafford GI, Elgorashi EE et al (2004) Assessing African medicinal plants for efficacy and safety: pharmacological screening and toxicology. J Ethnopharmacol 94:205–217
Fernández-Aparicio M, Delavault P, Timko MP (2020) Management of infection by parasitic weeds: a review. Plants 9:1184
Fernández-Aparicio M, Soriano G, Masi M, Carretero P, Vilariño-Rodríguez S, Cimmino A (2022) (4Z)-Lachnophyllum lactone, an acetylenic furanone from Erigeron bonariensis, identified for the first time with allelopathic activity against Cuscuta campestris. Agriculture 12:790
Ferreira MI, Lopes AP, Barroso JG (2020) Biological activities and chemical composition of Achillea millefolium L. Ind Crops Prod 147:112222
Ferreira RC, Duarte SS, de Sousa VM, de Souza RRM, Marques KKG, de Abrantes RA et al (2023) The essential oil from Conyza bonariensis (L) Cronquist (Asteraceae) exerts an in vitro antimelanoma effect by inducing apoptosis and modulating the MAPKs NF-κB and PKB/AKT signaling pathways. Pharmaceuticals 16:1553
Girma Y, Jiru TM (2021) Evaluation of antimicrobial activity of Erigeron bonariensis leaf extracts against clinically isolated fungi causing superficial infection. J Chem 2021:1–8
Hao G et al (2010) Flavonoids from Artemisia annua L. inhibit seed germination and root growth of lettuce (Lactuca sativa L.). Allelopathy J 25:289–296
Hernández JC, Vidal ML, Zamora SM (2020) Phytochemical profiles and allelopathic comparison of invasive Asteraceae: implications for weed management. Phytochem Rev 19(4):853–867. https://doi.org/10.1007/s11101-020-09650-7
Ibrahim WW et al (2024a) Neuroprotective potential of Erigeron bonariensis ethanolic extract. Inflammopharmacology 32:1–22. https://doi.org/10.1007/s10787-024-01266-0
Ibrahim WW, Sayed RH, Abdelhameed MF, Omara EA, Nassar MI, Abdelkader NF, Afifi SM (2024b) Neuroprotective potential of Erigeron bonariensis ethanolic extract against ovariectomized/D-galactose-induced memory impairments in female rats in relation to its metabolite fingerprint as revealed using UPLC/MS. Inflammopharmacology 32:1–22. https://doi.org/10.1007/s10787-024-01266-0
Khan TA, Khan JV (2018) Aeginetia indica L. and Conyza bonariensis (L.) Cronq are new distributional records in Satpuda range of Khandesh region, Maharashtra. Biosci Discov 9(4):498–500
Khatoon S, Ali M, Jabeen K (2022) Ecological impact and allelopathic potential of Parthenium hysterophorus: A review. Environ Chall 7:100483. https://doi.org/10.1016/j.envc.2022.100483
Kimura Y, Hiraoka K, Kawano T, Fujioka S, Shimada A (2008) Nematicidal activities of acetylene compounds from Coreopsis lanceolata L. Z Naturforsch C 63(11–12):843–847. https://doi.org/10.1515/znc-2008-11-1210
Kong LD, Abliz Z, Zhou CX, Li LJ, Cheng CHK, Tan RX (2001) Glycosides and xanthine oxidase inhibitors from Erigeron bonariensis. Phytochemistry 58(4):645–651. https://doi.org/10.1016/S0031-9422(01)00226-8
Kouadio KK, Mensah JK, Akpa EE (2022) Bioactive profile and anti-inflammatory potential of Erigeron bonariensis leaf extract. J Ethnopharmacol 285:114927. https://doi.org/10.1016/j.jep.2021.114927
Kuklev DV, Domb AJ, Dembitsky VM (2013) Bioactive acetylenic metabolites. Phytomedicine 20(13):1145–1159. https://doi.org/10.1016/j.phymed.2013.06.013
Kushwaha P, Bisht DS (2016) Chemical composition of volatile extract of Erigeron bonariensis and its antimicrobial activity
Luo Y, Zhang Q, He W (2021) Allelopathic effects of Ambrosia artemisiifolia on selected crop species. Ecotoxicol Environ Saf 220:112414. https://doi.org/10.1016/j.ecoenv.2021.112414
Mahanur VB, Rajge RR, Pal RS, Chaitanya MVNL, Vishwas S, Gupta S, Singh SK (2023) Harnessing unexplored medicinal values of red listed South African weed Erigeron bonariensis: From ethnobotany to biomedicine. S Afr J Bot 160:535–546
Maia JGS, da Silva MHL, Zoghbi MDGB, Andrade EHA (2002) Composition of the essential oils of Erigeron bonariensis (L.) Cronquist. J Essent Oil Res 14(5):325–326
Malatji MW (2013) Allelopathic potential of Erigeron bonariensis. Doctoral Dissertation, University of Pretoria
Müller M, Leuschner C, Schmidt W (2019) Invasive potential and allelopathy of Centaurea stoebe in European habitats. Plant Ecol 220(4):495–508
Nava-Solis U, Rodriguez-Canales M, Hernandez-Hernandez AB, Velasco Melgoza DA, Moreno-Guzman BP, Rodriguez-Monroy MA, Canales-Martinez MM (2022) Antimicrobial activity of the methanolic leaf extract of Prosopis laevigata. Sci Rep 12(1):20807
Oncho DA, Ejigu MC, Urgessa OE (2021) Phytochemical constituent and antimicrobial properties of guava extracts of east Hararghe of Oromia Ethiopia. Clin Phytosci. https://doi.org/10.1186/s40816-021-00268-2
Opiyo SA, Ogwang PE, Nyakundi WO (2023) Phytochemical characterization of bioactive compounds from Erigeron species and their potential applications. J Ethnopharmacol 298:115764. https://doi.org/10.1016/j.jep.2023.115764
Peralta AC, Soriano G, Zorrilla JG, Masi M, Cimmino A, Fernández-Aparicio M (2022) Characterization of Conyza bonariensis allelochemicals against broomrape weeds. Molecules 27(21):7421. https://doi.org/10.3390/molecules27217421
Polat DÇ, İlgün S, Karatoprak GŞ, Akkol EK, Capasso R (2022) Phytochemical profiles, antioxidant, cytotoxic, and anti-inflammatory activities of traditional medicinal plants: Centaurea pichleri subsp. pichleri Conyza canadensis and Jasminum fruticans. Molecules 27(23):8249
Prasad A, Wouters F, Roy A, Lenssen JPM (2018) Phytochemical analysis and antimicrobial potential of Erigeron bonariensis L. Int J Pharmacogn Phytochem Res 10(5):193–198
Rajput VD, Minkina T, Behal A (2022) Phytochemical diversity and allelopathic potential of Tagetes minuta L. Plants 11(4):537
Ribeiro AI, Sousa AM, Pires CS (2023) Ultrasound-assisted extraction enhances antibacterial potency of E. bonariensis phenolics. Phytochem Rev 22(2):311–327. https://doi.org/10.1007/s11101-022-09895-3
Rodríguez MA, Silva GR, Pérez DJ (2023) Inhibition of NF-κB pathway by flavonoids from Erigeron bonariensis. J Inflamm Res 19(1):134–141
Scalon SPQ, Bovi MLA, Souza LAC, Barbosa L, Basi S, Davide LC (2016) Allelopathic potential of Erigeron bonariensis (L.) Cronquist on the germination and initial growth of Lactuca sativa L. Planta Daninha 34(1):45–54. https://doi.org/10.1590/s0100-83582016340100005
Shah D, Raza MA, Saeed A, Riasat M, Chattha FI, Javaid M, Ullah S (2012) Antioxidant potential of the extracts of Putranjiva roxburghii, Erigeron bonariensis, Woodfordia fruiticosa and Senecio chrysanthemoids. Afr J Biotechnol 11(18):4288–4295
Shah NZ, Muhammad N, Azeem S, Khan AZ, Samie M, Khan H (2013) Antimicrobial and phytotoxic properties of Conyza bonariensis. Pharm Pharmacol Res 1(1):8–11
Silva RA, de Oliveira CA, Lima FM (2021) Antiproliferative effects of sesquiterpenes from Erigeron bonariensis on hepatic carcinoma cells. Phytochem Rev 20(5):1289–1304. https://doi.org/10.1007/s11101-021-09746-5
Singh P, Sharma N, Dubey RC (2021) Allelopathic influence of sunflower (Helianthus annuus) residues on wheat. Allelopathy J 53(2):217–226
Souto AL, Sylvestre M, Tölke ED, Tavares JF, Barbosa-Filho JM, Cebrián-Torrejón G (2021) Plant-derived pesticides as an alternative to pest management and sustainable agricultural production: Prospects, applications and challenges. Molecules 26(16):4835
Thabit RA, Cheng XR, Al-Hajj N, Rahman MRT, Lei G (2014) Antioxidant and Conyza bonariensis: a review. Eur Acad Res 2(6):8454–8474
Thabit RA, Cheng XR, Tang X, Sun J, Shi YH, Le GW (2015) Antioxidant and antibacterial activities of extracts from Conyza bonariensis growing in Yemen. Pak J Pharm Sci 28(1):129–134
Vieira LM, Teixeira SS, Matias CJ (2022) Antioxidant and anti-inflammatory potential of compounds isolated from Erigeron bonariensis. Nat Prod Res 36(9):1238–1248.
Viggiano SM et al (2020) Evolution of herbicide resistance in Erigeron bonariensis: Challenges and opportunities. Agron J 112(2):663–670
Wadankar GD, Khanzode MS, Mahale BK, Gavhale AP (2022) Phytochemical screening of Ricinus communis and Erigeron bonariensis. Int J Environ Agric Biotech 7(3):79–83
Westwood JH, Charudattan R, Duke SO, Fennimore SA, Marrone P, Slaughter DC, Zollinger R (2018) Weed management in 2050: perspectives on the future of weed science. Weed Sci 66(3):275–285
Allelopathy and Plant Taxonomy Laboratory, Department of Botany, Faculty of Life Science, Aligarh Muslim University, Aligarh, India