Evaluation of antioxidant, anti-inflammatory and antidiabetic activities of green synthesized silver nanoparticles and in vivo plant extracts of Nothapodytes foetida

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Research Articles | Published:

Print ISSN : 0970-4078.
Online ISSN : 2229-4473.
Pub Email: contact@vegetosindia.org
Doi: 10.1007/s42535-022-00481-5
First Page: 920
Last Page: 928
Views: 1392

Keywords: Silver nanoparticles, Anti-inflammatory, Antioxidant, Methanolic extracts, Antidiabetic, Nothapodytes foetida


Nothapodytes foetida, is an important endangered medicinal plant with potential alkaloids. These phytoconstituents aid in the treatment of several human ailments. The current study was conducted to reveal the in vitro antioxidant, anti-inflammatory and antidiabetic activities of N. foetida plant extracts and green synthesized silver nanoparticles. The antioxidant activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, H2O2 radical scavenging and reducing power assays; whereas anti-inflammatory activity was determined by the Human red blood cell (HRBC) membrane stabilization method and antidiabetic activity by α-amylase and α-glucosidase inhibition assays. Among all the samples tested, green synthesized silver nanoparticles exhibited potent antioxidant activity by DPPH radical scavenging (80.04 ± 0.12%), H2O2 radical scavenging (78.62 ± 0.41%) and reducing power assay (0.168 ± 0.39); potent anti-inflammatory activity (89.80 ± 0.67%) and antidiabetic activity by α-amylase (80.43 ± 0.74%) and α-glucosidase (79.19 ± 0.51%). These findings strengthen the medicinal properties of N. foetida and provide a basis for the development of new drugs.

Silver nanoparticles, Anti-inflammatory, Antioxidant, Methanolic extracts, Antidiabetic, 
              Nothapodytes foetida

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The authors sincere thankful to Council of Scientific and Industrial Research (CSIR-HRDG) New Delhi, India, for financial support and carry out this research work under Junior Research Fellowship (F.NO.09/384(0166)/2019- EMR-I).

Author Information

Dharavath Sunitha Bai
Department of Biotechnology, Kakatiya University, Warangal, India

Chirumamilla Pavani
Department of Biotechnology, Kakatiya University, Warangal, India

Taduri Shasthree
Department of Biotechnology, Kakatiya University, Warangal, India