Vegetos
(An International Journal of Plant Research & Biotechnology)
Evaluation of phytochemical, antimicrobial, antioxidant, antidiabetic, antigenotoxic, antimutagenic and cytotoxic potential of leaf extracts of Lantana camara
Sharma Amit, Dhanda Anita, Naveen, Aggarwal Neeraj K., Singh Ajay, Kumar Pankaj
Research Articles | Published: 20 August, 2024
First Page: 1218
Last Page: 1227
Views: 2215
Keywords: n Lantana camaran , Antimicrobial, Antioxidant, Antigenotoxic, Antimutagenic, Antidiabetic, Cytotoxic activity
Abstract
Lantana camara occupies a position among the most toxic weeds. All this lends the basis for this investigation to explore its leaf extract’s potential of antimicrobial, antioxidant, antigenotoxic, antimutagenic, antidiabetic, and cytotoxic activity. The yield proportion for extract in the range of 9.5 to 18.9% was explored herein. In both, total polyphenol content (TPC) and total flavonoid content (TFC) were revealed to 57.1 ± 1.7 mg gallic acid equivalent/g of sample and 21.1 ± 0.8 mg of catechin equivalent/g of sample respectively. Similalry, the free radical scavenging capacity of the extract lies in the range of 18.5 ± 0.8 to 62.2 ± 1.9 μg/mL. Ethyl acetate extract hit the maximum MIC terms (25 mg/ml and 18 mm inhibitory zone) against B. cereus. Antidiabetic findings indicate that methanol leaf (42 and 44% inhibition) extracts demonstrated the highest α-amylase and α-glucosidase inhibitory activity. Antigenotoxic (Comet assay) 1 mg/mL proportion finds its way through antigenotoxic potential of several extracts of (8.3 ± 1.0) tail moment. In a nutshell, different plant extracts possess mutagenic inhibition of 34% (methanolic extract) against the TA98 strain (− S9) at a concentration of 1 mg/mL plate. Similarly, cytotoxicity (MTT assay) (MCF-7, HT-29 and CHO) for methanol leaves extract for L. camara carry out about 80, 78, and 81% of inhibition respectively. Acquired evidences favors methanolic extract of L. camara (leaves) best among pharmaceutics as to cure various diseases.
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Author Information
Department of Microbiology, Kurukshetra University, Kurukshetra, India