Vegetos

---

Short Communications | Published: 11 March, 2025

References

---

Agreles MAA, Cavalcanti IDL, Cavalcanti IMF (2021) The role of essential oils in the inhibition of efflux pumps and reversion of bacterial resistance to antimicrobials. Curr Microbiol 78(10):3609–3619


Ahmed S et al (2019) Environmental factors variably impact tea secondary metabolites in the context of climate change. Front Plant Sci 10:939


Álvarez-Martínez FJ et al (2021) Antibacterial plant compounds, extracts and essential oils: an updated review on their effects and putative mechanisms of action. Phytomedicine 90:153626


Barbosa AJC et al (2021) Composição química e atividade antibacteriana dos óleos essenciais de Croton urticifolius LAM. e Croton adamantinus Müll. Arg. (Euphorbiaceae)


Bastos-Cavalcante N et al (2020) Phytochemical analysis, antibacterial activity and antibiotic modifying action of Jatropha mollissima (Pohl.) Baill. (Euphorbiaceae). Anales de Biología. Servicio de Publicaciones de la Universidad de Murcia, pp 85–94


Brasileiro BG et al (2006) Antimicrobial and cytotoxic activities screening of some Brazilian medicinal plants used in Governador Valadares district. Rev Bras Ciênc Farm 42(2):195–202


Butler MS et al (2022) Analysis of the clinical pipeline of treatments for drug-resistant bacterial infections: despite progress, more action is needed. Antimicrob Agents Chemother 66(3):e01991-e2021


Chaughule RS, Barve RS (2024) Role of herbal medicines in the treatment of infectious diseases. Vegetos 37(1):41–51


Chaves BJ, Tadi P (2023) Gentamicin. StatPearls. StatPearls Publishing, Treasure Island, FL


Cheema HS et al (2024) Antibiotic potentiation through phytochemical-based efflux pump inhibitors to combat multidrug resistance bacteria. Med Chem 20(6):557–575


Chumkaew P, Srisawat T (2021) A new flavone from Oroxylum indicum and its antibacterial activity. Chem Nat Compd 57:274–276


Coutinho HDM et al (2008) In vitro anti-staphylococcal activity of Hyptis martiusii Benth against methicillin-resistant Staphylococcus aureus: MRSA strains. Rev Bras 18:670–675


de Alencar NMM et al (2010) An anti-inflammatory lectin from Luetzelburgia auriculata seeds inhibits adhesion and rolling of leukocytes and modulates histamine and PGE2 action in acute inflammation models. Inflamm Res 59:245–254


de Vasconcelos AL (2012) Perfil anatômico fitoquímico, antimicrobiano e citotóxico de Luetzelburgia auriculata (allemao) Ducke. Dissertação de Mestrado. Universidade Federal de Pernambuco


Dias MC, Pinto DCGA, Silva AMS (2021) Plant flavonoids: chemical characteristics and biological activity. Molecules 26(17):5377


Ding C-F et al (2019) Thalicfoetine, a novel isoquinoline alkaloid with antibacterial activity from Thalictrum foetidum. Tetrahedron Lett 60(41):151135


Freitas TS et al (2021) UPLC-QTOF-MS/MS analysis and antibacterial activity of the Manilkara zapota (L.) P Royen against Escherichia coli and other MDR bacteria. Cell Mol Biol 67(1):116–124


Gallucci MN et al (2009) Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus. Flavour Fragr J 24(6):348–354


Grimsey EM et al (2020) Chlorpromazine and amitriptyline are substrates and inhibitors of the AcrB multidrug efflux pump. Mbio. https://doi.org/10.1128/mbio.00465-20


Houghton PJ et al (2007) Uses and abuses of in vitro tests in ethnopharmacology: visualizing an elephant. J Ethnopharmacol 110(3):391–400


Hu R et al (2020) Ethnobotanical study on medicinal plants used by Mulam people in Guangxi, China. J Ethnobiol Ethnomed 16:1–50


Huang W et al (2022) Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants. Antibiotics 11(10):1380


Javadpour MM et al (1996) De novo antimicrobial peptides with low mammalian cell toxicity. J Med Chem 39(16):3107–3113


Jernigan JA et al (2020) Multidrug-resistant bacterial infections in US hospitalized patients, 2012–2017. N Engl J Med 382(14):1309–1319


Karak P (2019) Biological activities of flavonoids: an overview. Int J Pharm Sci Res 10(4):1567–1574


Khare T et al (2021) Exploring phytochemicals for combating antibiotic resistance in microbial pathogens. Front Pharmacol 12:720726


Kumar G, Tudu AK (2023) Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors. Bioorgan Med Chem 80:117187


Lefebvre T, Destandau E, Lesellier E (2021) Selective extraction of bioactive compounds from plants using recent extraction techniques: a review. J Chromatogr A 1635:461770


Li Y et al (2020) The effect of developmental and environmental factors on secondary metabolites in medicinal plants. Plant Physiol Biochem 148:80–89


Lima LB et al (2022) Chemical and antibacterial analysis of Cinnamomum verum leaves extract and fractions against multidrug resistant bacteria. Nat Prod Res 36(10):2559–2564


Maher C, Hassan KA (2023) The Gram-negative permeability barrier: tipping the balance of the in and the out. Mbio 14(6):e01205-e1223


Marshall RL et al (2020) New multidrug efflux inhibitors for Gram-negative bacteria. Mbio. https://doi.org/10.1128/mbio.01340-20


Martins TF et al (2018) A Bowman-Birk inhibitor from the seeds of Luetzelburgia auriculata inhibits Staphylococcus aureus growth by promoting severe cell membrane damage. J Nat Prod 81(7):1497–1507


Matos FJA (1997) Introdução à fitoquímica experimental, 2nd edn. Edições UFC, Fortaleza, Brazil


Melo VMM et al (2005) A cotyledonary agglutinin from Luetzelburgia auriculata inhibits the fungal growth of Colletotrichum lindemuthianum, Fusarium solani and Aspergillus niger and impairs glucose-stimulated acidification of the incubation medium by Saccharomyces cerevisiae cells. Plant Sci 169(3):629–639


Moreira MAS et al (2008) Resistência a antimicrobianos dependente do sistema de efluxo multidrogas em Escherichia coli isoladas de leite mastítico. Arq Bras Med Vet Zootec 60:1307–1314


Murugaiyan J et al (2022) Progress in alternative strategies to combat antimicrobial resistance: focus on antibiotics. Antibiotics 11(2):200


Oo T et al (2021) Inhibition of bacterial efflux pumps by crude extracts and essential oil from Myristica fragrans Houtt. (nutmeg) seeds against methicillin-resistant Staphylococcus aureus. Molecules 26(15):4662


Oulahal N, Degraeve P (2022) Phenolic-rich plant extracts with antimicrobial activity: an alternative to food preservatives and biocides? Front Microbiol 12:753518


Peechakara BV, Gupta M (2022) Ampicillin/sulbactam. StatPearls [Internet]. StatPearls Publishing, pp 7–9


Pinto ÉNF et al (2015) Efeitos alelopáticos do pau pedra (Luetzelburgia auriculata (Allemão) Ducke) sobre a germinação e o desenvolvimento da alface (Lactuca sativa L.)


Pinto É et al (2018) Allelopathic effects of aqueous extract of leaves and roots of Luetzelburgia auriculata (Allemo) Ducke on seeds germination and initial growth of lettuce (Lactuca sativa L.). Afr J Agric Res 13(13):635–643


Pulingam T et al (2022) Antimicrobial resistance: prevalence, economic burden, mechanisms of resistance and strategies to overcome. Eur J Pharm Sci 170:106103


Rios J-L, Recio MC (2005) Medicinal plants and antimicrobial activity. J Ethnopharmacol 100(1–2):80–84


Sena BS, Lucchese AM (2017) Avaliação da composição química e atividade antioxidante dos extratos e frações de folha de Luetzelburgia auriculata (ALEMÃO) Ducke. Anais Semin Iniciaç Cient 7:8. https://doi.org/10.13102/semic.v0i21.2632


Silva DD et al (2020) Características morfológicas de frutos, sementes e plântulas de Luetzelburgia auriculata (Allemão) Ducke-Fabaceae. Res, Soc Dev 9(8):e545986133


Sinsinwar S, Vadivel V (2020) Catechin isolated from cashew nut shell exhibits antibacterial activity against clinical isolates of MRSA through ROS-mediated oxidative stress. Appl Microbiol Biotechnol 104:8279–8297


Soares EL et al (2007) Characterization and insecticidal properties of globulins and albumins from Luetzelburgia auriculata (Allemao) Ducke seeds towards Callosobruchus maculatus (F) (Coleoptera: Bruchidae). J Stored Prod Res 43(4):459–467


Song L et al (2022) Antibacterial modes of herbal flavonoids combat resistant bacteria. Front Pharmacol 13:873374


Souza AB et al (2023) Antibacterial activity and anxiolytic-like effect of Ziziphus joazeiro Mart. leaves in adult zebrafish (Danio rerio). Fish Shellfish Immunol Rep 5:100108


Sykes EME et al (2023) Salicylic acids and pathogenic bacteria: new perspectives on an old compound. Can J Microbiol 70(1):1–14


Tavares TD et al (2020) Activity of specialized biomolecules against gram-positive and gram-negative bacteria. Antibiotics 9(6):314


Thai T, Salisbury BH, Zito PM (2023) Ciprofloxacin. StatPearls [Internet]. StatPearls Publishing, pp 7–9


Ullah R et al (2020) A review on ethno-medicinal plants used in traditional medicine in the Kingdom of Saudi Arabia. Saudi J Biol Sci 27(10):2706–2718


Varela MF et al (2021) Bacterial resistance to antimicrobial agents. Antibiotics 10(5):593


Verma P, Tiwari M, Tiwari V (2021) Strategies to combat bacterial antimicrobial resistance: a focus on mechanism of the efflux pumps inhibitors. SN Compr Clin Med 3:510–527


Waditzer M, Bucar F (2021) Flavonoids as inhibitors of bacterial efflux pumps. Molecules 26(22):6904


Zhang L et al (2024) Bacterial efflux pump inhibitors reduce antibiotic resistance. Pharmaceutics 16(2):170

 

Author Information

---

Departamento de Química Biológica, Universidade Regional do Cariri, Crato, Brasil