Vegetos
(An International Journal of Plant Research & Biotechnology)
Anticancer properties of Roselle (Hibiscus sabdariffa L), review article
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Review Articles | Published: 04 October, 2024
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Keywords: Roselle parts, Constituents, Cancer cells
Abstract
The calyx, leaves, roots, stems, seeds and callus of Roselle (Hibiscus sabdariffa L) are abundant in phytochemicals such as fatty acids (oleic, octadecanoic and arachidic), anthocyanins, flavonoids, phenols and gossypetin. Hence, offering a great deal of potential for contemporary therapeutic applications. This study aimed to review and document all available evidence and information about various parts of Roselle with a special focus on their bioactive constituents and their activities in treating cancer. Previous studies have proven that Roselle calyx can be used to fight cancer cells, especially oral, breast, lung, colon and leukemia cancer cells. While leukemia, prostate, and liver cancer cells can be combated using Roselle leaves. Roselle roots have the potential to be employed as an antitumor agent. Roselle stems and seeds are utilized to fly melanoma cells. Cervical and colon cancer cells can be eradicated using Roselle callus. Global properties of Roselle parts point to the possibility of significant medicinal uses, which would increase the plant’s value.
References
Abeda HZ, Kouassi MK, Yapo KD, Koffi E, Sie RS, Kone M, Kouako HT (2014) Production and enhancement of anthocyanin in callus line of Roselle (Hibiscus sabdariffa L.). Int J Rec Biotech 2:45–56
Ahmed AMA, Talaat IM, Khalid AK (2017) Citric acid affects Melissa officinalis L. essential oil under saline soil. Asian JCrop Sci 9:40–49
Ajiboye BO, Akinnusi PA, Fatoki TH, Adigun DK, Adewole ZO, Efekemo EO, Ayotunde BT, Julius BP, Falode JA, Ajuwon OR, Oyinloye BE (2023) In silico assessment of Hibiscus sabdariffa as a possible therapeutic agent for breast cancer management. Inform Med Unlock 41:101330
Akhlaghi E, Lehto RH, Torabikhah M, Sharif Nia H, Taheri A, Zaboli E, Yaghoobzadeh A (2020) Chemotherapy use and quality of life in cancer patients at the end of life: an integrative review. Health Qual Life Outcomes 18:332
Akim A, Ling LC, Rahmat A, Zakaria ZA (2015) Antioxidant and anti-proliferative activities of Roselle juice on Caov-3, MCF-7, MDA-MB-231 and HeLa cancer cell lines. Int J Med Sociol Anthropol 4:1–9
Anwar SL, Wahyono A, Aryandono T, Haryono SJ (2015) Caveolin-1 in breast cancer: single molecule regulation of multiple key signaling pathways. Asian Pac J Cancer Prev 16:6803–6812
Bassong TR, Kenmogne LV, Awounfack CF, Ndinteh DT, Njamen D, Zingue S (2022) Effects of Hibiscus sabdariffa calyxes aqueous extract on antioxidant status and histopathology in mammary tumor induced in rats. Evid-Based Compl Alter Med 2022(1):13
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality world-wide for 36 cancers in 185 countries, CA Cancer. J Clin 68:394–424
Carrillo C, Cavia Mdel M, Alonso-Torre SR (2012) Antitumor effect of oleic acid;mechanisms of action: a review. Nutr Hosp 27:1860–1865
Chang-Qing Y, Jie L, Shi-Qi Z, Kun Z, Zi-Qian G, Ran X, Hui-Meng L, Ren-Bin Z, Gang Z, Da-Chuan Y, Chen-Yan Z (2020) Recent treatment progress of triple negative breast cancer. Prog Biophys Mol Biol 151:40–53
Chew LY, Teng SK, Neo YP, Sim Y, Chew SC (2024) The potential of Roselle (Hibiscus sabdariffa) plant in industrial applications: A promising source of functional compounds. J Oleo Sci 73:275–292
Chiu CT, Chen JH, Chou FP, Lin H (2015a) Roselle leaf extract inhibits human prostate cancer cell invasion via down regulation of Akt/NF-κB/MMP-9 pathway. Nutrients 7:5065–5087
Chiu CT, Chen JH, Chou FP, Lin HH (2015b) Hibiscus sabdariffa leaf extract inhibits human prostate cancer cell invasion via down-regulation of Akt/NF-kB/MMP-9 pathway. Nutrients 7:5065–5087
Coms S, Cîmpean AM, Raica M (2015) The story of MCF-7 breast cancer cell line: 40 years of experience in research. Anticancer Res 35:3147–3154
Crone M, Hallman K, Lloyd V, Szmyd M, Badamo B, Morse M, Dinda S (2019) The antiestrogenic effects of black cohosh on BRCA1 and steroid receptors in breast cancer cells. Breast Cancer 11:99–110
Da-Costa-Rocha I, Bonnlaender B, Sievers H, Pischel I, Heinrich M (2014) Hibiscus Sabdariffa L. A phytochemical and pharmacological review. Food Chem 165:424–443
Ding X, Zhang W, Li S, Yang H (2019) The role of cholesterol metabolism in cancer. Am J Cancer Res 9:219–227
Elkattan AN, El-Saadany SS, ElSayed AL, Abdalmuneim AMGJ (2019a) Anticancer effects tow traditional drinks hibiscus (Hibiscus sabdariffa LINN) and liquorice (Glycyrrhiza glabra). Zagazig J Agric Res 46(1):115–122
Elkattan AN, El-Saadany SS, ElSayed AL, Gomaa AM, Abdalmuneim J (2019b) Anticancer effects of two traditional beverages, hibiscus (Hibiscus sabdariffa LINN) and licorice (Glycyrrhiza glabra). Biotech Res 46:115–122
Erriquez J, Malacrida A, Menendez VR, Nicolini G, Miloso M (2016a) Antitumoral effects of Hibiscus Sabdarifa on human breast cancer cells. Ital J Anat Micobiol 121:143
Erriquez J, Malacrida A, Menendez VR, Nicolini G, Miloso M (2016b) Antitumoral effects of Hibiscus Sabdariffa on human breast cancer cells. Italian J Anat Emry 21(1):143
Fithrotunnisa Q, Arsianti A, Kurniawan G, Qorina F, Tejaputri NA, Azizah N (2020) In vitro cytotoxicity of Hibiscus sabdariffa linn extracts on A549 lung cancer cell line. Pharmacogn J 12(1):14–19
Formagio ASN, Ramos DD, Vieira MC, Ramalh SR, Silva MM, Zárate NAH, Fogli M, Carvalho JE (2015) Phenolic compounds of Hibiscus sabdariffa and influence of organic residues on its antioxidant and antitumoral properties. Braz J Biol 75(1):69–76
Fuentes N, Silveyra P (2019) Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol 116:135–170
Hanahan D, Weinberg R (2000) The hallmarks of cancer. Cell 100(1):57–70
Hasi R, Hasi AH, Islam M, Habib R, Satter MA, Yeasmin T (2019a) Antioxidant and antineoplastic activities of roots of Hibiscus sabdariffa linn against ehrlich ascites carcinoma cells. Clin Phytosci 5:46
Hasi RY, Ali H, Islam M, Habib R, Satter MA, Tanzima Y (2019) Antioxidant and antineoplastic activities of roots of Hibiscus sabdariffa linn against ehrlich ascites carcinoma cells. Clin Phytosci 5(1):46
Hilakivi C, Estrogens L (2000) BRCA1, and breast cancer. Cancer Res 60:4993–5001
Huang Z, Yu P, Tang J (2020) Characterization of triple-negative breast cancer MDAMB-231 cell spheroid model. OncoTargets Ther 13:5395–5405
Huang K, Liu Z, Kim M, Kim KR (2023) Anticancer effects of gossypetin from Hibiscus sabdariffa in oral squamous cell carcinoma. J Appl Oral Sci 31:e20230243
Ibrahim ME, Mohamed MA, Khalid KA (2014) Effect of growing locations on the essential oil content and compositions of lemon verbena shrubs under the conditions of Egypt. J Essent Oil Bear Plant 17:288–294
Jarzabek K, Koda M, Kozlowski L, Mittre H, Sulkowski S, Kottler ML, Wolczynski S (2005) Distinct mRNA, protein expression patterns and distribution of oestrogen receptors alpha and beta in human primary breast cancer: correlation with proliferation marker Ki-67 and clinic pathological factors. Eur J Cancer 41:2924–2934
Jiang H, Sun J, Xu Q, Liu Y, Wei J, Young CY, Yuan H, Lou H, Marchantin M (2013) A novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells. Cell Death Dis 4:e761
Kabir SR, Rahman MM, Amin R, Karim MR, Mahmud ZH, Hossain MT (2016) Solanum tuberosum lectin inhibits Ehrlich ascites carcinoma cells growth by inducing apoptosis and G2/M cell cycle arrest. Tumour Biol 37:8437–8444
Kaulika N, Febriansah R (2019) Chemopreventive activity of Roselle’s hexane fraction against breast cancer by In-vitro and in silico study. Adv Health Sci Res 15
Kay MA (2011) State-of-the-art gene-based therapies: the road ahead. Nat Rev Genet 12:316–328
Khaghani S, Razi F, Yajloo M, Paknejad M, Shariftabrizi A, Pasalar P (2011a) Selective cytotoxicity and Apoptogenic activity of Hibiscus Sabdariffa Aqueous extract against MCF-7 human breast cancer cell line. J Cancer Ther 2:394–400
Khaghani S, Razi F, Yajloo MM, Paknejad M, Shariftabrizi A, Pasalar P (2011) Selective cytotoxicity and apoptogenic activity of Hibiscus sabdariffa aqueous extract against MCF-7 human breast cancer cell line. J Cancer Ther 2:394–400
Khalid AK, Ahmed AMA (2021) Effect of soil type on grapefruit and shaddock essential oils. J Soil Sci Plant Nut 21:2048–2056
Khalid AK, Cai W, Aisha MAA (2009) Effect of harvesting treatments and distillation methods on the essential oil of lemon balm and apple geranium plants. J Essent Oil Bear Plant 12:120–130
Khalid AK, El-Gohary AE, Ahmed AMA (2020) Raising the efficiency of lemon trees to produce essential oil by exogenous cysteine under various soil structures. J Essent Oil Bear Plant 23:194–203
Khalid AK, Darwesh OM, Ahmed AMA (2021) Peel essential oils of Citrus types and their antimicrobial activities in response to various growth locations in Egypt. J Essent Oil Bear Plant 24:480–499
Khosravi-Shahi P, Cabezon-Gutierrez L, Aparicio-Salcedo MI (2019) State of art of advanced triple negative breast cancer. Breast J 25:967–970
Laskar YB, Mazumder PB (2020) Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus Sabdariffa L. Biomed Pharmacother 127:1–10
Lin H, Chan K, Sheu J, Hsuan S, Wang C, Chen J (2012) Hibiscus sabdariffa leaf induces apoptosis of human prostate cancer cells in vitro and in vivo. Food Chemi 132:880–891
Malacrida A, Erriquez J, Hashemi M, Rodriguez-Menendez V, Cassetti A, Cavaletti G, Miloso M (2022a) Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells. Biochem Biophys Rep 32:101353
Malacrida A, Erriquez J, Hashemi M, Rodriguez-Menendez V, Cassetti A, Cavaletti G, Miloso M (2022b) Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells. Biochem Biophys 27:101353
Mandisa PS, Benjamin IO, Vincent IO, Mervin M, Yapo GA (2023a) In vitro Antioxidant mechanism of action of Hibiscus Sabdariffa in the induction of apoptosis against breast cancer. J Herb Spic Med Plant 29(3):213–228
Mandisa P, Sobantu BI, Okeleye VI, Okudoh MM, Yapo GA (2023b) In vitro antioxidant mechanism of action of Hibiscus sabdariffa in the induction of apoptosis against breast cancer. J Herb Spice Med Plant 29:213–228
Milanesi L, Russo de Boland A, Boland R (2008) Expression and localization of estrogen receptor alpha in the C2C12 murine skeletal muscle cell line. J Cell Biochem 104:1254–1273
Monje P, Zanello S, Holick M, Boland R (2011) Differential cellular localization of estrogen receptor alpha in uterine and mammary cells. Mol Cell Endocrinol 181:117–129
Mungole A, Chaturvedi A (2011) Hibiscus sabdariffa L a rich source of secondary metabolites. Int J Pharma Sci RevRes 6:018
Nguyen QV, Chuyen HV (2020) Processing of herbal tea from Roselle (Hibiscus Sabdariffa L.): effects of drying temperature and brewing conditions on total soluble solid, phenolic content, antioxidant capacity and sensory quality. Beverages 6:1–11
Nunes AT, Annunziata CM (2017) Proteasome inhibitors: structure and function. Semin Oncol 44:377–380
Patani N, Martin LA, Reis-Filho JS, Dowsett M (2012) The role of caveolin-1 in human breast cancer. Breast Cancer Res Treat 131:1–15
Patel S (2014) Hibiscus Sabdariffa: an ideal yet under exploited candidate for nutraceutical applications. Biomed Prev Nutr 4:23–27
Pijuan J, Barcelo C, Moreno DF, Maiques O, Siso P, Marti RM, Maci A, Panosa A (2017) Cell migration, invasion, and adhesion assays: from cell imaging to data analysis. Front Cell Dev Biol 7:107
Prabhakaran D, Senthamilselvi MM, Rajeshkanna A (2017) Anticancer activity of Hibiscus sabdariffa. L (Flowers) against human liver cancer (Hepg2) cell line. Int J Chem Tech Res 10(12):351–356
Radiš R, Kuzmickienė I, Milinavi CE, Everatt R (2016) Hypertension, serumlipids and cancer risk: a review of epidemiological evidence. Medicin 52:89–98
Romano A, Feola A, Porcellini A, Gigantino V, Di Bonito M, Di Mauro A, Caggiano R, Faraonio R, Zuchegna C (2020) Estrogen induces selective transcription of Caveolin1 variants in human breast cancer through estrogen responsive element dependent mechanisms. Int J Mol Sci 21(17):5989
Rosen EM, Fan S, Pestell RG, Goldberg ID (2003) BRCA1 gene in breast cancer. J Cell Physiol 196:19–41
Salis O, Bedir A, Gulten S, Okuyucu A, Kulcu C, Alacam H (2014) Cytotoxic effect of fluvastatin on MCF-7 cells possibly through a reduction of the mRNA expression levels of SGK1 and CAV1, cancer biother. Radiopharm 29:368–437
Schneider R, Barakat A, Pippen J, Osborne C (2011) Aromatase inhibitors in the treatment of breast cancer in post-menopausal female patients: an update. Breast Cancer 3:113–125
Sehim AE, Amin BH, Yosri M, Salama HM, Alkhalifah DH, Alwaili MA, Abd- Elghaffar RY (2023) GC-MS analysis, antibacterial, and anticancer activities of Hibiscus sabdariffa L. methanolic extract: In vitro and in silico studies. Microorganisms 11(6):1601
Sehim AE, Amin BH, Yosri M, Salama HM, Alkhalifah DH, Alwaili MA, Abd Elghaffar RY (2023) GC-MS analysis, antibacterial, and anticancer activities of Hibiscus sabdariffa L methanolic extract in vitro and in silico studies. Microorganisms 11(6):1601
Selimovic D, Porzig BB, El-Khattouti A, Badura HE, Ahmad M, Ghanjati F, Santourlidis S, Haikel Y, Hassan M (2013) Bortezomib proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells. Cell Signal 25:308–318
Serafini M, Stanzione A, Foddai S, Anton R, Delmulle L (2012) The European role on traditional herbal medicinal products and traditional plant food supplements. J Clin Gastroenterol 46:S93–S94
Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics. CA Cancer J Clin 64:9–29
Sindi HA, Marshall LJ, Morgan MR (2014) Comparative chemical and biochemical analysis of extracts of Hibiscus Sabdariffa. Food Chem 164:23–29
Swaminathan A, Nanjian R (2020) Bioactive compounds isolated from in vitro callus and wild plant of Hibiscus Sabdariffa Linn and it’s anticancer activities. Proceedings of International Conference on Drug Discovery (ICDD)
Tanaka K (2009) The proteasome: overview of structure and functions. Proc Jpn Acad Ser B Phys Biol Sci 85:12–36
Umamaheswari A, Govindan N (2007) Anticancerous effect of Hibiscus sabdariffa leaves on Hepatocellular Carcinoma cell line hep 3B. Res J Med Plan 1:100–105
Wang H, Lu C, Tan Y, Xie J, Jiang J (2014) Effect of adriamycin on BRCA1 and PARP-1 expression in MCF-7 breast cancer cells. Int J Clin Exp Pathol 7:5909–5915
Welboren WJ, Stunnenberg HG, Sweep FC, Span PN (2007) Identifying estrogenreceptor target genes. Mol Oncol 1:138–143
Wojcik S (2013) Crosstalk between autophagy and proteasome protein degradation systems: possible implications for cancer therapy. Folia Histochem Cytobiol 51:249–264
Wu J, Lu LY, Yu X (2010) The role of BRCA1 in DNA damage response. Protein Cell 1:17–23
Xu XY, Choi HS, Park SY, Kim JK, Seo KH, Kim H, Kim YJ (2022) Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression. Phytomedicine 95:153870
Yao S, Hu Q, Kerns S, Yan L, Onitilo AA, Misleh J, Young K, Lei L, Bautista J, Mohamed J, Mohile SG, Ambrosone CB, Liu S, Janelsins MC (2019) Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study. Clin Epigenetics 11:45
Yin SY, Wei WC, Jian FY, Yang NS (2013) Therapeutic applications of herbal medicines for cancer patients. Evid Based Complement Alternat Med 2013(1):15
Yuliastri WO, Diantini A, Ghozali M, Sahidin I, Isrul M (2022) Phytochemical constituents and In-vitro cytotoxic activity of Hibiscus sabdariffa L. calyx fraction on human breast cancer cell line MDA-MB-231. Rasayan J Chem 15(3):1619–1625
Yuliastri WO, Diantini A, Ghozali M, Sahidin I, Isrul M (2022b) Phytochemical constituents and in vitro cytotoxic activity of the calyx fraction of Hibiscus plant on human breast cancer cell line MDA-MB-231. Rasayan J Chem 15:1619–1625
Yun CW, Lee S H (2018) The roles of autophagy in cancer. Int J Mol Sci 19.
Zou M, Li Y, Xia S, Chu Q, Xiao X, Qiu H, Chen Y, Zheng Z, Liu F, Zhuang L, Yu S (2017) Knockdown of CAVEOLIN-1 sensitizes human basal-like triple-negative breast cancer cells to radiation. Cell Physiol Biochem 44:778–791
Author Information
Botany Department, National Research Centre, Cairo, Egypt