Comparative evaluation of antioxidant, antiglycation and α-glucosidase inhibitory potential of some indigenous medicinal Trigonella species

Research Articles | Published:

Print ISSN : 0970-4078.
Online ISSN : 2229-4473.
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Doi: 10.1007/s42535-022-00543-8
First Page: 1337
Last Page: 1346
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Keywords: Antiglycation, Antioxidant, India, n Trigonellan


The aim of the present study was to comprehensively and comparatively investigate the antioxidant, antiglycation and α-glucosidase inhibitory potential of some indigenous medicinal Trigonella species. T. uncata with its higher phenolic and flavonoid content showed maximum inhibition of α-glucosidase activity as compared to other species. Methanolic seed extract of T. corniculata had maximum 2,2-Diphenyl-L-Picrylhydrazyl (DPPH) radical scavenging activity while that of T. glabra had maximum reducing power and total antioxidant activity. Aqueous seed extracts of all tested species exerted noticeable antiglycation potential with inhibition of fructosamine and β-amyloid aggregate formation (R = 0.950, p < 0.05) and reduction in carbonyl levels and increase in free thiol groups (R = 0.684, p < 0.05) well correlated. Results indicate that T. glabra, with its α-glycosidase inhibitory potential, higher antioxidant activity coupled with stronger protection of albumin against oxidation can be combined with T. foenum-graecum in polyherbal formulations for treating diabetic complications.

Antiglycation, Antioxidant, India, n              Trigonellan

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Author Information

Gaonkar Namdeo
Department of Cell and Molecular Biology, Bharati Vidyapeeth (Deemed to be) University, Rajiv Gandhi Institute of IT and Biotechnology, Pune, India