Vegetos

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Review Articles | Published: 08 April, 2026

References

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Abbas S, Shahbaz M, Ali A et al (2025) Casticin: a natural flavonoid with promising pharmacological and biological activities. Fitoterapia, p106746


Abd El-Hack ME, Aldhalmi AK, Kamal M, et al (2025) Flavonoids as a phytobiotic agent: sources, classifications, biological benefits, and useful impacts on broilers and layers. Phytochem Rev, pp 1–27


Al Hoque A, Begum S, Dutta D (2025) Occurrence, chemical nature, and medicinal benefits of flavonoids-rutin, kaempferol, quercetin, anthocyanidins, catechins, and flavones. dietary supplements and nutraceuticals. Springer Nature, Singapore, pp 1–24


Al-Dissi A, El-Sayed EM, Abdo SA, Al-Qudah MA (2019) The anti-angiogenic activity of selected dietary phytochemicals: a review. Pharmacogn Rev 13(25):11–20. https://www.phcogrev.com/article/2019/13/25/1013PR06


Alharbi HOA, Alshebremi M, Babiker AY, Rahmani AH (2025) The role of quercetin, a flavonoid in the management of pathogenesis through regulation of oxidative stress, inflammation, and biological activities. Biomolecules 15(1):151


Al-Khayri JM, Sahana GR, Nagella P, et al (2022) Flavonoids as potential anti-inflammatory molecules: a review. In:: Lucie 27:2901. https://doi.org/10.3390/molecules27092901


Arora J, Sharma V, Ramawat KG (2025) Isoflavonoids. Natural products: phytochemistry, botany, metabolism of alkaloids, phenolics and terpenes. Springer, Heidelberg, pp 1–22


Arts IC, Hollman PC (2005) Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 81(suppl1):317S–325S. https://pubmed.ncbi.nlm.nih.gov/15640498/


Cai Y, Liang YC, Hu XY, et al (2025) Inverse association between dietary flavonoid intake and nocturia in middle-aged and older adults from NHANES 2007–2010. Sci Rep 15(1):4423


Chávez-González ML, Sepúlveda L, Verma DK et al (2020) Conventional and emerging extraction processes of flavonoids. Processes 8:434. https://doi.org/10.3390/pr8040434


Chen Y, Yu D, Zhu D et al (2025) Exploring alkaloids and flavonoids from natural sources: emerging natural agents for inhibiting cervical cancer progression through apoptosis induction, anti-inflammatory effects, and oxidative stress reduction. Pathology-Research and Practice, p 156092


Ciumărnean L, Milaciu MV, †, Runcan O, et al (2020) The effects of flavonoids in cardiovascular diseases. In: Celestino Santos-Buelga (ed) Molecules [Journal-article]. https://doi.org/10.3390/molecules25184320


Dias MC, Pinto DCGA, Silva AMS (2021) Plant flavonoids: chemical characteristics and biological activity. Molecules 5377. https://doi.org/10.3390/molecules26175377


Działo M, Mierziak J, Korzun U, Geppert D (2016) Flavonoids as anticancer agents molecules 21(7):903. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272517/


Forman HJ, Zhang H (2021) Targeting the Nrf2 pathway in cancer: a double-edged sword. J Funct Foods 81:104443. https://pubmed.ncbi.nlm.nih.gov/33732049/


Galati G, O’Brien PJ (2004) Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 37(3):287–303. https://doi.org/10.1016/j.freeradbiomed.2004.04.034


García-Lafuente A, Guillamón E, Villares A, Rostagno MA, Martínez JA (2009) Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 58(9):537–552. https://doi.org/10.1007/s00011-009-0037-3


Gayi BK, Aiduenu AF, Dofuor AK et al (2026) Significance and implications of prostate cancer: critical overview for future directions in Africa. Cancer Invest 1–22. https://doi.org/10.1080/07357907.2025.2598046


Giri S, Saha P (2025) Anti-inflammatory flavonoids found in medicinal plants of acanthaceae family. Indian J Nat Prod Resour (IJNPR)[Formerly Nat Prod Radiance (NPR)] 16(2):209–226


Gong S, Fei Y (2025) Moderate dietary flavonoid intake associated with lower prevalence of Parkinson’s disease: data from the NHANES 2007–2010 and 2017–2018. Neurol Res 47(5):406–419


Griffiths K, Aggarwal B, Singh R, Buttar H, Wilson D, De Meester F (2016) Food antioxidants and their anti-inflammatory properties: a potential role in cardiovascular diseases and cancer prevention. Diseases 4(3):28. https://doi.org/10.3390/diseases4030028


Hashim NT, Babiker R, Chaitanya NC et al (2025) New insights in natural bioactive compounds for periodontal disease: Advanced molecular mechanisms and therapeutic potential. Molecules 30(4):807


He J, Giusti MM (2010) Anthocyanins: Natural colorants with health-promoting properties. Annual Rev Food Sci Technol 1:163–187. https://doi.org/10.1146/annurev.food.080708.100754


Hossain MS, Wazed MA, Asha S, Amin MR, Shimul IM (2025) Dietary phytochemicals in health and disease: mechanisms, clinical evidence, and applications—a comprehensive review. Food Sci Nutr 13(3):e70101


Hu L, Luo Y, Yang J, Cheng C (2025) Botanical flavonoids: efficacy, absorption, metabolism and advanced pharmaceutical technology for improving bioavailability. Molecules 30(5):1184


Jiao Y, Li S, Wang X, Song Y, Yan Z, Li F (2018) Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Mol Med Rep 18(4):3691–3696. https://pubmed.ncbi.nlm.nih.gov/30066914/


Jomova K, Alomar SY, Valko R, Nepovimova E, Kuca K, Valko M (2025) The role of redox-active iron, copper, manganese, and redox-inactive zinc in toxicity, oxidative stress, and human diseases. EXCLI J 24:880–954


Kandaswami C, Lee LT, Lee PP, Hwang JJ, Ke FC, Huang YT, Lee MT (2005) The antitumor activities of flavonoids. Vivo 19(5):895–909


Kannan G, Paul BM, Thangaraj P (2025) Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review. Inflammopharmacology 33(1):145–162


Kejík Z, Kaplánek R, Masařík M, et al (2021) Iron complexes of flavonoids-antioxidant capacity and beyond. Int J Mol Sci 22(2). https://doi.org/10.3390/ijms22020646


Khan H, Ullah H, Castilho PCMF, et al (2020) Targeting NF-κB signaling pathway in cancer by dietary polyphenols. Crit Rev Food Sci Nutr 60(16):2790–2800. https://doi.org/10.1080/10408398.2019.1661827


Kopustinskiene DM, Jakstas V, Savickas A, Bernatoniene J (2020) Flavonoids as anticancer agents. Nutrients 12(2):457. https://doi.org/10.3390/nu12020457


Ku Y, Ng M, Cheng S, Lo AW, Xiao Z, Shin T, Chung G, Lam H (2020) Understanding the composition, biosynthesis, accumulation and transport of flavonoids in crops for the promotion of crops as healthy sources of flavonoids for human consumption. Nutrients 12(6):1717. https://doi.org/10.3390/nu12061717


Kumar R, Kamboj N, Gunsola D, Karmakar R, Chattaraj S, Gangola S (2025) Phytonutrients: harnessing anti-inflammatory and anti-cancer potential for health benefits. Curr Res Nutr Food Sci J 13(Special Issue Phytonutrients July 2025):53–71


Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. Sci World J 162750. https://doi.org/10.1155/2013/162750


Li H, Liu Z, Lu H, Chen H (2020) Targeting PI3K/Akt/mTOR pathway by different flavonoids: a cancer chemopreventive approach. Cancers 12(12):3749. https://www.mdpi.com/2072-6694/12/12/3749


Liga S, Paul C, Péter F (2023) Flavonoids: Overview of biosynthesis, biological activity, and current extraction techniques. In Sabater-Jara Ana Belén, Lorena Almagro (eds) Plants Vol 12, p 2732. https://doi.org/10.3390/plants12142732


Link A, Balaguer F, Goel A (2010) Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem Pharmacol 80(12):1771–1792. https://doi.org/10.1016/j.bcp.2010.06.036


Liskova A, Koklesova L, Samec M, et al (2020) Flavonoids in cancer metastasis. Cancers 12:1498. https://doi.org/10.3390/cancers12061498


Maharjan PM, Bains S, Lale PK, Bhargava P, Gautam RK (2022) An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway. Phytother Res 36(2):705–728. https://pubmed.ncbi.nlm.nih.gov/34747065/


Marzocchella L, Fantini M, Benvenuto M, Masuelli L, Tresoldi I, Modesti A, Galvano F (2011) Dietary flavonoids: molecular mechanisms of action as anti-inflammatory agents. Recent Pat Inflamm Allergy Drug Discov 5(3):200–220


Maurya AK, Vinayak M (2015) The natural flavonoid fisetin inhibits cellular proliferation of hepatic, colorectal, and pancreatic cancer cells through modulation of multiple signaling pathways. PLoS ONE 10(7):e0132367. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132367


Meer N, Elamin A, Mohammed F, Bashir F, Tayyem R (2026) Dietary polyphenols as anticancer agents: a review of recent advances and mechanisms. Nutr Health 02601060251411197. https://doi.org/10.1177/02601060251411197


MishraRR(2024) Phytochemical analysis and comparison of some selected plants. Vegetos 1–12. https://doi.org/10.1007/s42535-024-01062-4


Mitek M, Mitek M, Majdan M (2020) The role of flavonoids in cancer prevention and therapy: the current state of knowledge. Nutrients 12(6):1604. https://www.mdpi.com/2072-6643/12/6/1604


Murota K, Nakamura Y, Uehara M (2018) Flavonoid metabolism: the interaction of metabolites and gut microbiota. Biosci Biotechnol Biochem 82(4):600–610


Niharika, Parveen R, Parveen B, Umar S, Ahmad S (2026) A comprehensive review on indigenous therapeutic approaches in kidney care using Ayush medicine. Front Pharmacol 16:1588424. https://doi.org/10.3389/fphar.2025.1588424


Nowakowska Z (2007) A review of anti-infective and anti-inflammatory chalcones. Eur J Med Chem 42(2):125–137. https://doi.org/10.1016/j.ejmech.2006.09.019


Okamoto D, Anantharaman A (2025) Comprehensive cancer care and lifestyle medicine. lifestyle medicine: closing research, practice, and knowledge gaps. Springer Nature Switzerland, Cham, pp 299–324


Pal A, Goel F, Sharma A, Garg VK (2025) Oxidative stress and antioxidant therapeutics in autism spectrum disorder: a biochemical and structure–activity relationship perspective. Mol Diversity 1–19


Pan X, Tang S, Gong X, Yu J, Jiang S, Su Y, Li Y (2020) Anti-inflammatory activity of flavonoids in cancer: a review. Frontiers in Pharmacology 11:1025. https://www.frontiersin.org/articles/10.3389/fphar.2020.01025/full


Pandey P, Lakhanpal S, Mahmood D, et al (2025) An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway. Front Pharmacol 15:p1513422


Petersen K, Mansell TJ (2025) Unveiling the prebiotic potential of polyphenols in gut health and metabolism. Curr Opin Biotechnol 95:103338


Ponte LGS, Pavan ICB, Mancini MCS et al (2021) The hallmarks of flavonoids in cancer. In: Francesca Giampieri (ed), Molecules Vol 26, p 2029. https://doi.org/10.3390/molecules26072029


Prasad S, Gupta SC, Tyagi AK, Aggarwal BB (2010) Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv 32(6):1053–1064. https://doi.org/10.1016/j.biotechadv.2014.04.004


Pratheeshkumar P, Budhraja A, Son YO et al (2012) Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR-2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS ONE 7(10):e47516. https://doi.org/10.1371/journal.pone.0047516


Pyo Y, Kwon KH, Jung YJ (2024) Anticancer potential of flavonoids: their role in cancer prevention and health benefits. Foods 13(14):2253. https://doi.org/10.3390/foods13142253


Ramprasath LM, Sankar A (2020) Phytochemical insights into flavonoids in cancer: mechanisms, therapeutic potential, and the case of quercetin. Biomed Pharmacother 121:109590. https://pubmed.ncbi.nlm.nih.gov/31756543/


Rao MJ, Zheng B (2025) The role of polyphenols in abiotic stress tolerance and their antioxidant properties to scavenge reactive oxygen species and free radicals. Antioxidants 14(1):74


Rauf A, Imran M, Khan H, Shah M, Hassan SZ (2018) Fisetin: A dietary flavonoid with multi-targeted health benefits. Chemico-Biol Interact 279:16–24. https://pubmed.ncbi.nlm.nih.gov/29080646/


Ren W, Qiao Z, Wang X, Zhu L (2018) The hallmarks of flavonoids in cancer. Antioxidants 7(12):177. https://www.mdpi.com/2076-3921/7/12/177


Romagnolo DF, Selmin OI (2012) Flavonoids and cancer prevention: a review of the evidence. J Nutr Gerontol Geriatr 31(3):206–238. https://doi.org/10.1080/21551197.2012.702534


Speisky H, Shahidi F, Costa de Camargo A, Fuentes J (2022) Revisiting the oxidation of flavonoids: loss, conservation or enhancement of their antioxidant properties. Antioxid (Vol 11:133. https://doi.org/10.3390/antiox11010133


Rostampour K, Alipour K, Mirjalili F, et al (2025) Dietary flavonoids and lung cancer: a GRADE-assessed systematic review and meta-analysis of observational studies. Nutr Cancer 77(2):164–178


Roy P, Amita T, Neha G (2019) Flavones: six selected flavones and their related signaling pathways that induce apoptosis in cancer. Nutr Cancer 71(6):920–942. https://pubmed.ncbi.nlm.nih.gov/31206148/


Russo GL, Tedesco I, Spagnuolo C, Russo M (2012) Antioxidant polyphenols in cancer treatment: friend, foe or foil? Sem Cancer Biol 22(4):303–311. https://doi.org/10.1016/j.semcancer.2012.03.002


Sak K (2016) Cytotoxicity of flavonoids and their derivatives against cancer cells: a review. Toxicol In Vitro 34:148–163. https://pubmed.ncbi.nlm.nih.gov/27040445/


Serafini M, Peluso I, Raguzzini A (2010) Flavonoids as anti-inflammatory agents. Proc Nutr Soc 69(3):273–278. https://doi.org/10.1017/S002966511000162X


Shan F, Liu L, Li L, Wang W, Bi Y, Li M (2025) Management, safety, and efficacy evaluation of nutraceutical and functional food: a global perspective. Compr Rev Food Sci Food Saf 24(4):e70222


Sharma G, Taliyan R, Kumar R (2023) Flavonoids as promising natural compounds against cancer: recent trends and future perspectives. J Funct Foods 100:105370. https://pubmed.ncbi.nlm.nih.gov/36698642/


Sharma H, Anand A, Halagali P et al (2024) Advancement of nanoengineered flavonoids for chronic metabolic diseases. Role Flavonoids Chronic Metabolic Diseases: Bench Clin 459–510


Silva-Pinto PA, de Pontes JTC, Aguilar-Morón B et al (2025) Phytochemical insights into flavonoids in cancer: mechanisms, therapeutic potential, and the case of quercetin. Heliyon 11(4)


Singh A, Kaur P, Kumar M et al (2025) The role of phytochemicals in modulating the gut microbiota: implications for health and disease. Med Microecology 100125


Singh S, Goswami N, Kumar A, Gautam RK (2022) Flavonoids as promising molecules in the cancer therapy: an insight. Food Chem Toxicol 166:113175. https://pubmed.ncbi.nlm.nih.gov/35764350/


Singh A, Singh J, Parween G, Khator R, Monga V (2024) A comprehensive review of apigenin a dietary flavonoid: biological sources, nutraceutical prospects, chemistry and pharmacological insights and health benefits. Crit Rev Food Sci Nutr 1–37


Stachelska MA, Karpiński P, Kruszewski B (2025) A comprehensive review of biological properties of flavonoids and their role in the prevention of metabolic, cancer and neurodegenerative diseases. Appl Sci 15(19):10840. https://doi.org/10.3390/app151910840


Sun J, Sha M, Zhou J, Huang Y (2025) Quercetin affects apoptosis and autophagy in pediatric acute myeloid leukaemia cells by inhibiting PI3K/AKT signaling pathway activation through regulation of miR-224-3p/PTEN axis. BMC Cancer 25(1):318


Tang S, Wang B, Liu X, et al (2025) Structural insights and biological activities of flavonoids: implications for novel applications. Food Front 6(1):218–247


Tiwari R, Mondal Y, Bharadwaj K, Mahajan M, Mondal S, Sarkar A (2025) Reactive oxygen species (ROS) and their profound influence on regulating diverse aspects of cancer: a concise review. Drug Dev Res 86(4):e70107


Tufail T, Fatima S, Ul Ain B, et al (2025) Role of phytonutrients in the prevention and treatment of chronic diseases: a concrete review. ACS omega 10(13):12724–12755


Tumilaar SG, Hardianto A, Dohi H, Kurnia D (2024) A comprehensive review of free radicals, oxidative stress, and antioxidants: overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds. J Chem 20241:5594386


Ullah A, Munir S, Badshah SL et al (2020) Important flavonoids and their role as a therapeutic agent. Molecules. https://doi.org/10.3390/molecules25225243


Vo HVT, Patton GN, Kim SJ, Kim N, Lee HJ (2025) Exploring flavonoids as regulators of NF--2 and MMP‐9 in cancer pathogenesis. Chem Biol Drug Des 105(6):e70145


Wilson AJ, Chueh AC, Tögel L, Corner GA, Young GP (2016) Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. Cancer Res 70(2):609–620


Yi M, Wu X, Zhuang W, Xia L, Chen Y, Mai W (2017) Dietary flavonoids and the risk of gastric cancer: a meta-analysis. PLoS ONE 12(2):e0171974. https://doi.org/10.1371/journal.pone.0171974


You AJ, Park J, Shin JM, Kim TH (2025) Oxidative stress and dietary antioxidants in head and neck cancer. Antioxidants 14(5):508


Yue M, Liu Y, Feng X, Cao B, Fei X, Li G, Li C (2025) Epimedii folium flavonoids: a double-edged sword effect on the liver, a dual exploration of efficacy and toxicity. J Pharm Anal. 101269


Zawawi NA, Ahmad H, Madatheri R, Fadilah NIM, Maarof M, Fauzi MB (2025) Flavonoids as natural anti-inflammatory agents in the atopic dermatitis treatment. Pharmaceutics 17(2):261. https://doi.org/10.3390/pharmaceutics17020261


Zeng Y, Lu X, Wang Y, He J, Cao H, Zhang L, Cheng L (2025) Recent status and trends regarding oxidative stress in gliomas (2013–2025): a systematic review and bibliometric analysis. Front Oncol 15:1586515


Zhang W, Chen T (2021) Flavonoids and Wnt/β-catenin signaling pathway in cancer: a systematic review. Front Pharmacol 12:658603. https://www.frontiersin.org/articles/https://doi.org/10.3389/fphar.2021.658603/full


Zheng J, Yang B, Huang Y, Li S, Wang S, Tang G (2017) Flavonoid intake and cancer risk: a systematic review and meta-analysis of cohort studies. Nutr Cancer 69(8):1115–1127. https://pubmed.ncbi.nlm.nih.gov/28901844/


Zheng X, Zhang X, Zeng F (2025) Biological functions and health benefits of flavonoids in fruits and vegetables: a contemporary review. Foods 14(2):155


Zverev YF, Rykunova AY (2022) Modern nanocarriers as a factor in increasing the bioavailability and pharmacological activity of flavonoids. Appl Biochem Microbiol 58(9):1002–1020


Panche AN, Diwan AD, Chandra SR (2016) Flavonoids: an overview. J NutritionalScience 5:e47. https://doi.org/10.1017/jns.2016.41


Harborne JB, Williams CA (2000) Advances in flavonoid research since 1992. Phytochemistry 55(6):481–504. https://doi.org/10.1016/S0031-9422(00)00235-1


Hollman PCH, Katan MB (1999) Dietary flavonoids: intake, health effectsand bioavailability. Food Chem Toxicol 37(9–10):937–942. https://doi.org/10.1016/S0278-6915(99)00079-4


Messina M (2014) Soy foods,isoflavones, and the health of postmenopausal women. Am J Clin Nutr 100:423S–430S. https://doi.org/10.3945/ajcn.113.071464


Williamson G, Kay CD, Crozier A (2018) The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective. Compr Rev FoodSci Food Saf 17:1054–1112. https://doi.org/10.1111/1541-4337.12351


Selma MV, Espín JC, Tomás-Barberán FA (2009) Interaction between phenolicsand gut microbiota: role in human health. J Agric Food Chem 57(15):6485–6501. https://doi.org/10.1021/jf902107d

 

Author Information

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Amity Institute of Microbial Technology, Amity University Rajasthan, Jaipur, India