Jangid Ritu, Jain Shalini, Sharma Mukesh Kumar, Chatterjee Sreemoyee
Keywords:
Diabetes mellitus (DM), Natural products (NPs),
Prosopis juliflora
,
Prosopis cineraria
, Antioxidants
Diabetes Mellitus (DM) is a long-term chronic disorder that leads to high blood glucose levels. Type 2 diabetes mellitus (T2DM) is the most common type of DM which includes defects like insulin resistance and lower insulin secretion. The general strategies that are incorporated by people to treat T2DM are regular exercise, diet control, and consumption of various oral antidiabetic drugs (OADs). Despite their therapeutic benefits, these drugs tend to produce undesirable side effects. With the advantage of having several anti-diabetic bioactive reagents, natural products (NPs) are being considered a better alternative for the treatment of T2DM. These products are considered to be less toxic and have fewer side effects than allopathic medicines. The increased dependency of the people on plant-based products shows their urge to attain a collective defense against various ailments and diseases. So, the prime aim of this study is to investigate the antioxidant and anti-diabetic properties (at the in-vitro level) of ethanolic extracts of Prosopis species abundantly available in Rajasthan and are being used by the traditional medicine system to cure several ailments. For this investigation, commonly used assays like Folin–Ciocalteau, Aluminium-chloride colorimetric, FRAP, DPPH, and α-amylase DNSA have been performed. Apart from these assays, other quantitative evaluations of the Prosopis species have also been done, including GCMS and FTIR analysis. In this study, it has been observed that both the plants contain compounds like alkaloids, tannins, flavonoids, etc., and show several medicinal properties. However, the ethanolic bark extract of Prosopis cineraria contains large amounts of phenolic and flavonoid compounds that exhibit the highest antioxidant and free radical scavenging potential. This plant even exhibited better in vitro antidiabetic potential as compared to the other plant extract in consideration.
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Financial assistance provided by the Council of Scientific and Industrial Research (CSIR), New Delhi to Ms. Shalini Jain (File No. 09/1180(0003)/2019-EMR-I) in the form of CSIR-SRF (NET) is highly acknowledged.