Medicinal plants used for the treatment of cancer in Algeria: an ethnomedicinal survey

*Article not assigned to an issue yet

,


Research Articles | Published:

Print ISSN : 0970-4078.
Online ISSN : 2229-4473.
Website:www.vegetosindia.org
Pub Email: contact@vegetosindia.org
Doi: 10.1007/s42535-022-00445-9
First Page: 0
Last Page: 0
Views: 152


Keywords: Ethnomedicinal survey, Algeria, Medicinal plants, Cancer


Abstract


Cancer is a major health problem and the second leading cause of death in the world. Modern therapies for cancer may not be accessible to patients from developing countries due to unavailability, cost, and adverse effects. Medicinal plants as alternative medicine thus become the choice of treatment given their therapeutic properties, including in Algeria, where plant based traditional medicine is frequently used to treat several cancers. To examine the use of medicinal plants as treatment for cancer by the Algerian population, the present study conducted an ethnobotanical survey. This study identified eight plant species used to treat different types of cancer including lung, blood, breast, ovarian, uterine, otorhinolaryngologic (ORL), prostate and liver cancer. The most important species used to treat these cancers were: Ephedra alata, Anabasis articulata, Taraxacum officinale and Calligonum comosum, with Anabasis articulata and Calligonum comosum being reported for the first time to treat different types of cancers. Leaves were the most commonly used part of the plant, while decoction was the main method of preparation, and oral administration was the main mode of intake. Findings from the present study suggest that the local population from different regions in Algeria maintain full knowledge about medicinal plants used for cancer treatment, particularly lung cancer. These findings highlight the need to document and preserve the traditional medicine in managing cancer. This may give more insight into future pharmacological investigations on the identified plants to determine their efficacy and safety, which would inform wider scale treatment, thereby increasing global utility.


Ethnomedicinal survey, Algeria, Medicinal plants, Cancer


References


Abdallah HM, Abdel-Naim AB, Ashour OM, Shehata AI, Abdel-Sattar EA (2014) Anti-inflammatory activity of selected plants from Saudi Arabia. Zeitschr Naturfor C J Biosci 69(1–2):1–9


Ahmad R, Ahmad N, Naqvi AA, Shehzad A, Al-Ghamdi MS (2016) Role of traditional Islamic and Arabic plants in cancer therapy. J Tradition Complement Med 7(2):195–204. https://doi.org/10.1016/j.jtcme.2016.05.002


Akerreta S, Cavero RY, Calvo MI (2007) First Comprehensive contribution to medical ethnobotany of Western Pyrenees. J Ethnobiol Ethnomed 3:26. https://doi.org/10.1186/1746-4269-3-26


Akgul A, Akgul A, Senol SG, Yildirim H, Secmen O, Dogan Y (2018) An ethnobotanical study in Midyat (Turkey), a city on the silk road where cultures meet. J Ethnobiol Ethnomed 14:12. https://doi.org/10.1186/s13002-017-0201-8


Alami Merrouni I, Elachouri M (2021) Anticancer medicinal plants used by Moroccan people: ethnobotanical, preclinical, phytochemical and clinical evidence. J Ethnopharmacol 266:113435. https://doi.org/10.1016/j.jep.2020.113435


Alves-Silva JM, Romane A, Efferth T, Salgueiro L (2017) North African medicinal plants traditionally used in cancer therapy. Front Pharmacol 8:383. https://doi.org/10.3389/fphar.2017.00383


Amjad MS, Qaeem MF, Ahmad I, Ullah Khan S, Chaudhari SK, Malik NZ, Shaheen H, Mehmood Khan A (2017) Descriptive study of plant resources in the context of the ethnomedicinal relevance of indigenous flora: a case study from Toli Peer National Park, Azad Jammu and Kashmir, Pakistan. PLoS ONE 12(2):e0171896. https://doi.org/10.1371/journal.pone.0171896


Amjad MS, Zahoor U, Bussmann RW, Altaf M, Gardazi SMH, Abbasi AM (2020) Ethnobotanical survey of the medicinal flora of Harighal, Azad Jammu & Kashmir, Pakistan. J Ethnobiol Ethnomed 16(1):65. https://doi.org/10.1186/s13002-020-00417-w


Aziz MA, Adnan M, Hasan Khan A, Shahat AA, Al-Said MS, Ullah R (2018) Traditional uses of medicinal plants practiced by the indigenous communities at Mohmand Agency, FATA, Pakistan. J Ethnobiol Ethnomed 14:2. https://doi.org/10.1186/s13002-017-0204-5


Benarba B (2016) Medicinal plants used by traditional healers from South-West Algeria: an ethnobotanical study. J Intercult Ethnopharmacol 5(4):320–330. https://doi.org/10.5455/jice.20160814115725


Benarba B, Belabid L, Righi K, Bekkar AA, Elouissi M, Khaldi A, Hamimed A (2015) Ethnobotanical study of medicinal plants used by traditional healers in Mascara (North West of Algeria). J Ethnopharmacol 175:626–637. https://doi.org/10.1016/j.jep.2015.09.030


Bouafia M, Amamou F, Gherib M, Benaissa M, Azzi R, Nemmiche S (2021) Ethnobotanical and ethnomedicinal analysis of wild medicinal plants traditionally used in Naâma, Southwest Algeria. Vegetos 34(3):654–662. https://doi.org/10.1007/s42535-021-00229-7


Boudjelal A, Henchiri C, Madani S, Sarri D, Hendel N, Benkhaled A, Ruberto G (2013) Herbalists and wild medicinal plants in M’Sila (North Algeria): an ethnopharmacology survey. J Ethnopharmacol 148(2):395–402. https://doi.org/10.1016/j.jep.2013.03.082


Bourhia M, Shahat AA, Almarfadi OM, Naser FA, Abdelmageed WM, Ait Haj Said A, El Gueddari F, Naamane A, Benbacer L, Khlil N (2019) Ethnopharmacological survey of herbal remedies used for the treatment of cancer in the greater Casablanca-Morocco. Evid-Based Complement Alternat Med ECAM 2019:1613457. https://doi.org/10.1155/2019/1613457


Cerqueira TMG, de Carvalho Correia AC, dos Santos RV, Lemos RPL, da Silva SAS, Barreto E (2020) The use of medicinal plants in Maceió, Northeastern Brazil: an ethnobotanical survey. Medicines 7(2):7. https://doi.org/10.3390/medicines7020007


da Silva MG, da Silva RH, Damasceno Júnior GA, Guarim-Neto G (2019) Plants used by the rural community of Bananal, Mato Grosso, Brazil: aspects of popular knowledge. PLoS ONE 14(1):e0210488. https://doi.org/10.1371/journal.pone.0210488


Dai J, Mumper RJ (2010) Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules (basel, Switzerland) 15(10):7313–7352. https://doi.org/10.3390/molecules15107313


Debbarma M, Pala NA, Kumar M, Bussmann RW (2017) Traditional knowledge of medicinal plants in tribes of Tripura in Northeast India. Afr J Tradition Complement Alternat Med AJTCAM 14(4):156–168. https://doi.org/10.21010/ajtcam.v14i4.19


Eddouks M, Ajebli M, Hebi M (2017) Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet Region (Province of Errachidia), Morocco. J Ethnopharmacol 198:516–530. https://doi.org/10.1016/j.jep.2016.12.017


Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M et al (2020) Global cancer observatory: cancer today. International Agency for Research on Cancer, Lyon. https://gco.iarc.fr/today. Accessed March 2022


Ferreira Rodrigues Sarquis RSD, do Socorro R, Rodrigues Sarquis I, Rodrigues Sarquis I, Fernandes CP, da Silva GA, Lima Silva RB, Gonçalves Jardim MA, Sánchez-Ortíz BL, Tavares Carvalho JC (2019) The use of medicinal plants in the riverside community of the Mazagão River in the Brazilian Amazon, Amapá, Brazil: ethnobotanical and ethnopharmacological studies. Evid-Based Complement Alternat Med ECAM 2019:6087509. https://doi.org/10.1155/2019/6087509


Gezici C, Şekeroğlu N (2019) Current perspectives in the application of medicinal plants against cancer: novel therapeutic agents. Anti-Cancer Agents Med Chem 19(1):101–111. https://doi.org/10.2174/1871520619666181224121004


Hadjaidji-Benseghier F, Derridj A (2013) Relative importance of the exploitation of medicinal plants in traditional medicine in the Northeastern Sahara, Emirates. J Food Agric. https://doi.org/10.9755/ejfa.v25i9.14426


Hammiche V, Maiza K (2006) Traditional medicine in Central Sahara: pharmacopoeia of Tassili N’ajjer. J Ethnopharmacol 105(3):358–367. https://doi.org/10.1016/j.jep.2005.11.028


Heinrich M, Ankli A, Frei B, Weimann C, Sticher O (1998) Medicinal plants in Mexico: healers’ consensus and cultural importance. Soc Sci Med (1982) 47(11):1859–1871. https://doi.org/10.1016/s0277-9536(98)00181-6


Hussain W, Badshah L, Manzoor U, Maroof A, Asghar A, Farrukh H (2018) Quantitative study of medicinal plants used by the communities residing in Koh-e-Safaid Range, northern Pakistani-Afghan borders. J Ethnobiol Ethnomed 14:30. https://doi.org/10.1186/s13002-018-0229-4


Islam MDK, Saha S, Mahmud I, Mohamad K, Awang K, Uddin SJ, Rahman MDM, Shilpi JA (2014) An ethnobotanical study of medicinal plants used by tribal and native people of Madhupur Forest Area, Bangladesh. J Ethnopharmacol 151(2):921–930. https://doi.org/10.1016/j.jep.2013.11.056


Jaradat NA, Al-Ramahi R, Zaid AN, Ibrahim Ayesh O, Eid AM (2016) Ethnopharmacological survey of herbal remedies used for treatment of various types of cancer and their methods of preparations in the West Bank-Palestine. BMC Complement Alternat Med 16:93. https://doi.org/10.1186/s12906-016-1070-8


Kassa Z, Asfaw Z, Demissew S (2020) An ethnobotanical study of medicinal plants in Sheka Zone of southern nations nationalities and peoples regional state, Ethiopia. J Ethnobiol Ethnomed 16(1):7. https://doi.org/10.1186/s13002-020-0358-4


Kichu M, Malewska T, Akter K, Imchen I, Harrington D, Kohen J, Vemulpad SR, Jamie JF (2015) An ethnobotanical study of medicinal plants of Chungtia Village, Nagaland, India. J Ethnopharmacol 166:5–17. https://doi.org/10.1016/j.jep.2015.02.053


Lee C, Kim SY, Eum S, Paik JH, The Bach T, Darshetkar AM, Choudhary RK, Hai DV, Quang BH, Thanh NT, Choi S (2019) Ethnobotanical study on medicinal plants used by local Van Kieu ethnic people of Bac Huong Hoa Nature Reserve, Vietnam. J Ethnopharmacol 231:283–294. https://doi.org/10.1016/j.jep.2018.11.006


Malami I, Jagaba NM, Babangida Abubakar I, Muhammad A, Alhassan AM, Waziri PM, Yakubu Yahaya IZ, Mshelia HE, Mathias SN (2020) Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria. Heliyon 6(9):e04830. https://doi.org/10.1016/j.heliyon.2020.e04830


Malan DF, Neuba DFR, Kouakou KL (2015) Medicinal plants and traditional healing practices in Ehotile people, around the Aby Lagoon (Eastern Littoral of Côte d’Ivoire). J Ethnobiol Ethnomed 11:21. https://doi.org/10.1186/s13002-015-0004-8


Malik K, Ahmad M, Bussmann RW, Tariq A, Ullah R, Alqahtani AS, Shahat AA, Rashid N, Zafar M, Sultana S, Shah SN (2018) Ethnobotany of anti-hypertensive plants used in northern Pakistan. Front Pharmacol 9:789. https://doi.org/10.3389/fphar.2018.00789


Malik K, AhmaZ M, Zafar M, Ullah R, Mahmood HM, Parveen B, Rashid N, Sultana S, Shah SN, Lubna N (2019) An ethnobotanical study of medicinal plants used to treat skin diseases in northern Pakistan. BMC Complement Alternat Med 19(1):210. https://doi.org/10.1186/s12906-019-2605-6


Médail F (2004) Flore et végétation du Sahara, P. Ozenda, Paris. Ecol Mediterran 30(2):247


Meddour R, Meddour-Sahar O (2015) Medicinal plants and their traditional uses in Kabylia (Tizi Ouzou, Algeria). Arab J Med Aromat Plants 1(2):137–151. https://doi.org/10.48347/IMIST.PRSM/ajmap-v1i2.4331


Miara MD, Bendif H, Ait Hammou M, Teixidor-Toneu I (2018) Ethnobotanical survey of medicinal plants used by nomadic peoples in the Algerian Steppe. J Ethnopharmacol 219:248–256. https://doi.org/10.1016/j.jep.2018.03.011


Mükemre M, Behçet L, Çakılcıoğlu U (2015) Ethnobotanical study on medicinal plants in villages of Çatak (Van-Turkey). J Ethnopharmacol 166:361–374. https://doi.org/10.1016/j.jep.2015.03.040


Ochwang’i DO, Kimwele CN, Oduma JA, Gathumbi PK, Mbaria JM, Kiama SJ (2014) Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya. J Ethnopharmacol 151(3):1040–1055. https://doi.org/10.1016/j.jep.2013.11.051


Omara T, Kiprop AK, Ramkat RC, Cherutoi J, Kagoya S, Nyangena DM, Tebo TA, Nteziyaremye P, Karanja LN, Jepchirchir A, Maiyo A, Kiptui BJ, Mbabazi I, Nakiguli CK, Nakabuye BV, Chepkemoi Koske M (2020) Medicinal plants used in traditional management of cancer in Uganda: a review of ethnobotanical surveys, phytochemistry, and anticancer studies. Evid-Based Complement Alternat Med eCAM 2020:3529081. https://doi.org/10.1155/2020/3529081


Ouelbani R, Bensari S, Mouas TN, Khelifi D (2016) Ethnobotanical investigations on plants used in folk medicine in the regions of Constantine and Mila (North-East of Algeria). J Ethnopharmacol 194:196–218. https://doi.org/10.1016/j.jep.2016.08.016


Quézel P (1962) Nouvelle flore de l’Algérie et des régions désertiques méridionales. Éditions du Centre National de la Recherche Scientifique, Paris


Riadh H, Imen F, Abdelmajid Z, Sinda F (2011) Detection and extraction of anti-listerial compounds from Calligonum comosum, a medicinal plant from arid regions of Tunisia. Afr J Tradition Complement Alternat Med 8(3):322–327


Savikin K, Zdunić G, Menković N, Zivković J, Cujić N, Tereščenko M, Bigović D (2013) Ethnobotanical study on traditional use of medicinal plants in South-Western Serbia, Zlatibor district. J Ethnopharmacol 146(3):803–810. https://doi.org/10.1016/j.jep.2013.02.006


Shahat AA, Ullah R, Alqahtani AS, Alsaid MS, Husseiny HA, Al Meanazel OTR (2018) Hepatoprotective effect of Eriobotrya Japonica leaf extract and its various fractions against carbon tetra chloride induced hepatotoxicity in rats. Evid-Based Complement Alternat Med ECAM 2018:3782768. https://doi.org/10.1155/2018/3782768


Sigstedt SC, Hooten KJ, Callewaert MC, Jenkins AR, Romero AE, Pullin MJ, Kornienko A, Lowrey TK, Van Slambrouck S, Steelant WFA (2008) Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. Int J Oncol 32(5):1085–1090


Sivasankari B, Anandharaj M, Gunasekaran P (2014) An ethnobotanical study of indigenous knowledge on medicinal plants used by the village peoples of Thoppampatti, Dindigul District, Tamilnadu, India. J Ethnopharmacol 153(2):408–423. https://doi.org/10.1016/j.jep.2014.02.040


Srithi K, Balslev H, Wangpakapattanawong P, Srisanga P, Trisonthi C (2009) Medicinal plant knowledge and its erosion among the Mien (Yao) in Northern Thailand. J Ethnopharmacol 123(2):335–342. https://doi.org/10.1016/j.jep.2009.02.035


Sung H, Ferlay J, Siegel R L, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J Clin 71(3), 209–249. https://doi.org/10.3322/caac.21660


Taïbi K, Ait Abderrahim L, Ferhat K, Betta S, Taïbi F, Bouraada F, Boussaid M (2020) Ethnopharmacological Study of Natural Products Used for Traditional Cancer Therapy in Algeria. Saudi Pharma J SPJ 28(11):1451–1465. https://doi.org/10.1016/j.jsps.2020.09.011


Tardío J, Pardo-de-Santayana M (2008) Cultural importance indices: a comparative analysis based on the useful wild plants of Southern Cantabria (Northern Spain). Econ Bot 62(1):24–39. https://doi.org/10.1007/s12231-007-9004-5


Tesfaye S, Belete A, Engidawork E, Gedif T, Asres K (2020) Ethnobotanical study of medicinal plants used by traditional healers to treat cancer-like symptoms in eleven districts, Ethiopia. Evid-Based Complement Alternat Med eCAM 2020:7683450. https://doi.org/10.1155/2020/7683450


Tounekti T, Mahdhi M, Khemira H (2019) Ethnobotanical study of indigenous medicinal plants of Jazan region, Saudi Arabia. Evid-Based Complement Alternat Med ECAM 2019:3190670. https://doi.org/10.1155/2019/3190670


Trotter RT, Logan MH (1986) Informant consensus: a new approach for identifying potentially effective medicinal plants. In: Plants in indigenous medicine & diet. Routledge


World Health Organization (WHO) (2020) https://www.who.int/news-room/fact-sheets/detail/cancer. Accessed March, 2022


Yemele MD, Telefo PB, Lienou LL, Tagne SR, Fodouop CSP, Goka CS, Lemfack MC, PMoundipa F (2015) Ethnobotanical survey of medicinal plants used for pregnant women׳s health conditions in Menoua Division-West Cameroon. J Ethnopharmacol 160:14–31. https://doi.org/10.1016/j.jep.2014.11.017

 


Acknowledgements


We thank D. Hadj-Said for technical help. We would also like to thank all the people who helped us in gathering information during the interviews. We are also grateful to Bader Edine Lidi, Ali Bekakra and Moataz Hamaidi for sharing their valuable knowledge with us and participating in plant collection.


Author Information


Harbane Sonia
Ecology, Biotechnology and Health Lab, Mouloud Mammeri University of Tizi-Ouzou, Tizi-Ouzou, Algeria

Bouazza Belaid
Ecology, Biotechnology and Health Lab, Mouloud Mammeri University of Tizi-Ouzou, Tizi-Ouzou, Algeria

belaid.bouazza@ummto.dz