Vegetos
(An International Journal of Plant Research & Biotechnology)
Phytochemical screening of genus Cotoneaster through GC–MS profiling: an insight into medicinally relevant compounds
Research Articles | Published: 24 August, 2024
First Page: 2026
Last Page: 2034
Views: 1840
Keywords: n Cotoneastern , GCMS, Bioactive compounds, Therapeutics, Kashmir Himalayas
Abstract
The genus Cotoneaster (Rosaceae) comprises around 300 species globally, some of which have been used in traditional and regional medicine to treat numerous ailments. Although it has widespread use in conventional medicine, very little is known about its bioactive compounds, especially from the Kashmir Himalayan species. Therefore, the current study aimed to evaluate the volatile secondary metabolites through Gas Chromatography and Mass Spectrometry (GC–MS) of the fruit methanolic extracts of four Cotoneaster species viz, Cotoneaster nummularius, Cotoneaster affinis, Cotonesater microphylla, and Cotoneaster confusus growing in the Kashmir Himalayas. Among these species, C. nummularius showed the presence of ten compounds with Eicosanoic acid, methyl ester as the most abundant with a concentration of 70.70%, followed by methyl 20-methyl-heneicosanoate, 11-eicosenoic acid, and cis-methyl 11-eicosenoate with a concentration of 70.70%, 6.84%, 6.68%, and 6.65% respectively. Comparably, C. affinis s methanolic extract revealed the presence of four different bioactive chemicals, viz, Hexane, 1-methoxy representing the most substantial constituent at 20.71% followed by carbonic acid at 20.90%, phosphine at 19.60%, and triacontanoic acid at 19.18%. Similarly, C. microphylla revealed the existence of five different phytochemicals viz., Silane (10.97%), 1R-ethoxy-3-cis-methoxy-2-cis-methylcyclohexane (33.37%), 1,5-anhydro-d-altritol (34.21%), ethyl isopropylamino oximinoacetate (14.63%), and pentadecanoic acid (6.82%). Whereas, five different compounds such as methyl tropate (10.52%), aristol-1(10)-en-9-yl isovalerate (9.28%), 12,12-dimethyl-5,8,11,13,16,19-hexaoxa-12-silatricosane (12.02%), sorbitol (59.60%), and cyclohexanone, 2,6-bis(2-methylpropylidene) (8.58%) were found in the methanolic extracts of C. confusus. The compounds identified have anti-hypertensive, antioxidant, anticancer, anti-inflammatory, antifungal, antimicrobial, mitochondrial-reparative, red blood cell-stabilizing, and antifibrotic activities which affirms the therapeutic potential of these species.
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Author Information
Cytogenetics and Plant Molecular Biology Research Laboratory, Department of Botany, University of Kashmir, Srinagar, India